ORIGINAL RESEARCH

Investigation of mechanisms of sensibilization of tumor cells by new synthetic progestin buterol

Odintsova EV1, Fedotcheva TA1, Banin VV2, Shimanovsky NL1
About authors

1 P. V. Sergeev Department of Molecular Pharmacology and Radiobiology, Biomedical Faculty,
Pirogov Pirogov Russian National Research Medical University, Moscow, Russia

2 All-Russian Institute of Medicinal and Aromatic Plants, Moscow, Russia

Correspondence should be addressed: Elena Odintsova
ul. B. Pirogovskaya, d. 9a, Moscow, Russia, 119435; ur.xednay@awostnidol

Received: 2011-12-07 Accepted: 2012-06-05 Published online: 2017-01-05
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One of the most frequent problems in the chemotherapy of hormone dependent tumors is the development of resistance in tumor cells to cytostatics. The main role among possible mechanisms of such resistance plays overexpression of P-glycoprotein, MRP and BCRP — the ABC-transporters family proteins, and Bcl-2 — antiapoptotic protein. In this study new synthetic analog of progesterone — buterol — was investigated as a perspective sensibilizing compound, e.g. compound, which increases sensitivity to anticancer drugs. It was shown, that buterol strengthens cytostatic effect of doxorubicin and etoposid in breast cancer cells in vitro. Also it was demonstrated that buterol decreases BCRP, P-glycoprotein and MRP mRNA expression in common on the 10th day of incubation. Besides, buterol suppresses mRNA expression of Bcl-2. Thus mechanisms of sensitization in MCF-7 cells are associated with the decrease of transporter proteins expression and antiapoptotic Bcl-2 protein expression.

Keywords: multidrug resistance, progestins, breast cancer

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