ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Clinical, immunological and virological indicators of antiretroviral therapy efficiency
About authors
1 Department of Infectious Diseases, Medico-Prophylactic Faculty,
Kazan State Medical University, Kazan, Russia
2 Republic Center of AIDS and Infectious Diseases Prevention and Treatment, Kazan, Russia
Correspondence should be addressed: Alfiya F. Oleynik
prospekt Pobedy, d. 83, Kazan, Russia, 420140; ur.xednay@snoflaa
About paper
Acknowledgements: authors thank Niyaz Galiullin and Firaya Nagimova for the opportunity to conduct the study study at the Republic Center of AIDS and Infectious Diseases Prevention and Treatment (Kazan, Russia).
Contribution of the authors to this work: Oleynik AF — analysis of literature, research planning, data collection, analysis, and interpretation, drafting of a manuscript; Fazylov VH — analysis of literature, research planning, data interpretation, drafting a manuscript; Beshimov AT — research planning, data interpretation, drafting a manuscript. All authors participated in editing of the manuscript.
Received: 2017-01-31
Accepted: 2017-03-16
Published online: 2017-03-13
|
Fig. 1. Groups of patients by type of drug, three-component first line ART
NRTIs — nucleoside reverse transcriptase inhibitor; NNRTI — non-nucleoside reverse transcriptase inhibitor; PI — protease inhibitor; INI — integrase inhibitor; AZT — azidothymidine; ABC — abacavir; other NRTIs — stavudine, didanosine, phosphazide; 3TC — lamivudine; EFV — efavirenz; NVP — nevirapine; ETR — etravirine; LPV/r — lopinavir boosted with ritonavir; ATV/±r — atazanavir boosted/not boosted with ritonavir; DRV/±r — darunavir boosted/not boosted with ritonavir; other PI — fosamprenavir, saquinavir, indinavir, nelfinavir, ritonavir; RAL — raltegravir.
Fig. 2. Groups of patients by immunological response to ART (II — immunological ineffectiveness, IE — immunological effectiveness)
Table 1. Reasons for patients dismissal from the study
Note. ART — antiretroviral therapy, AVT — antiviral therapy (hepatitis).
Table 2. HIV resistance to antiretroviral drugs, test results (n = 34)
Note. ART — antiretroviral therapy; NRTIs — nucleoside reverse transcriptase inhibitor; NNRTI — non-nucleoside reverse transcriptase inhibitor; PI — protease inhibitor; AZT — azidothymidine; ABC — abacavir; 3TC — lamivudine; TDF — tenofovir; FTC — emtricitabinum; ddl — didanosinum; d4t — stavudinum; EFV — efavirenz; NVP — nevirapine; ETR — etravirine; DLV — delavirdine; LPV/r — lopinavir boosted with ritonavir; DRV/±r — darunavir boosted/not boosted with ritonavir; ATV — atazanavirum; SQV — saquinavirum; FPV — fosamprenavirum; IDV — indinavirum; NFV — nelfinavirum; TPV — tipranavirum.
