ГУДКОВ Андрей Владимирович

Старший вице-президент (фундаментальная наука),
заведующий лабораторией биологии клеточного стресса,
Онкологический институт имени Розвелла Парка (Буффало, Нью-Йорк, США)

PhD (онкология), д. б. н.

Научные интересы:

новые принципы, лекарства и мишени для профилактики и лечения рака; молекулярные и клеточные мишени и лекарственные препараты к ним для лечения старения; происхождение и контроль ретро-элементов, их роль в эволюции и современных патологиях

Особые достижения:

University Scholar, University of Illinois at Chicago (1999)
P. K. Ranney Foundation Award, Cleveland Clinic Foundation (2005)
Garman Family Chair in Cell Stress Biology, Roswell Park Cancer Institute (2008)
Thomas Tomasi Hope Award, Roswell Park Cancer Institute (2016)

О НАУКЕ:

Ключевые публикации за последние 5 лет

  1. Hall BM, Balan V, Gleiberman AS, Strom E, Krasnov P, Virtuoso LP, Rydkina E, Vujcic S, Balan K, Gitlin I, Leonova K, Polinsky A, Chernova OB, Gudkov AVAging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells. Aging (Albany NY). 2016; 8 (7): 1294–315.
  2. Komarov AP, Komarova EA, Green K, Novototskaya LR, Baker PS, Eroshkin A, Osterman AL, Chenchick AA, Frangou C, Gudkov AVFunctional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure. Cell Death Dis. 2016; 7: e2145.
  3. Brackett CM, Kojouharov B, Veith J, Greene KF, Burdelya LG, Gollnick SO, Abrams SI, Gudkov AVToll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis. PNAS. 2016 Feb 16; 113 (7): E874–83.
  4. Krivokrysenko VI, Toshkov I, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra R, Narizhneva N, Singh VK, Whitnall M, Purmal A, Shakhov A, Gudkov AV, and Feinstein E. TLR5 Agonist Entolimod Mitigates Acute Radiation Syndrome in Non-human Primates. PLoS One. 2015; 10 (9): e0135388.
  5. Natarajan V, Komarov AP, Ippolito T, Bonneau K, Chenchik AA, Gudkov AVPeptides genetically selected for NF-kB activation cooperate with oncogene Ras and model carcinogenic role of inflammation. PNAS. 2014; 111 (4): E474–83.
  6. Burdelya LG, Brackett CM, Kojouharov B, Gitlin II, Leonova K, Gleiberman AS, Aygun-Sunar S, Veith J, Johnson C, Haderski GJ, Stanhope-Baker P, Allamaneni S, Skitzki J, Zeng M, Martsen E, Medvedev A, Scheblyakov D, Artemicheva NM, Logunov DY, Gintsburg AL, Naroditsky BS, Makarov SS, Gudkov AVCentral role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonists. PNAS. 2013; 110 (20): E1857–66.
  7. Leonova KI, Brodsky L, Lipchick B, Pal M, Novototskaya L, Chenchik AA, Sen GC, Komarova EA, Gudkov AVp53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs. PNAS. 2013; 110 (1): E89–98.
  8. Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, Seluanov A. Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. PNAS. 2012; 109 (47): 19392–6.
  9. Spengler ML, Kuropatwinski KK, Comas-Soberats M, Gasparian AV, Fedtsova N, Gleiberman AS, Gitlin II, Artemicheva NM, Deluca KA, Gudkov AV, Antoch MP. Core circadian protein CLOCK is a positive regulator of NF-kB-mediated transcription. PNAS. 2012; 109 (37): E2457–65.
  10. Yoon S-I, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA. Structural Basis of TLR5-Flagellin Recognition and Signaling. Science. 2012; 335 (6070): 859–64.