ГУЛЯЕВА Наталия Валерьевна

Заместитель директора по науке,
руководитель лаборатории функциональной биохимии нервной системы,
Институт высшей нервной деятельности и нейрофизиологии РАН (Москва, Россия)

Д. б. н., профессор

Научные интересы:

нейробиология (нейрофизиология и патофизиология мозга, нейрохимия, молекулярные механизмы пластичности мозга и развития патологий, механизмы стрессоустойчивости и стресс-реактивности); трансляционная медицина (моделирование и исследование неврологических и психических патологий и параллельные нейрохимические исследования в клинике: эпилепсия, инсульт, депрессивно-тревожные расстройства, нейродегенеративные заболевания)

О НАУКЕ:

Ключевые публикации за последние 5 лет

  1. Peregud DI, Yakovlev AA, Stepanichev MY, Onufriev MV, Panchenko LF, Gulyaeva NV. Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent. Cell Mol Neurobiol. 2016 Aug; 36 (6): 839–49. DOI: 10.1007/s10571-015-0267-6.
  2. Fominykh V, Onufriev MV, Vorobyeva A, Brylev L, Yakovlev AA, Zakharova MN, Gulyaeva NV. Increased S-nitrosothiols are associated with spinal cord injury in multiple sclerosis. J Clin Neurosci. 2016 Jun; 28: 38–42. DOI: 10.1016/j.jocn.2015.09.017.
  3. Tishkina A, Stepanichev M, Kudryashova I, Freiman S, Onufriev M, Lazareva N, Gulyaeva N. Neonatal proinflammatory challenge in male Wistar rats: Effects on behavior, synaptic plasticity, and adrenocortical stress response. Behav Brain Res. 2016 May 1; 304: 1–10. DOI: 10.1016/j.bbr.2016.02.001.
  4. Piskunov A, Stepanichev M, Tishkina A, Novikova M, Levshina I, Gulyaeva N. Chronic combined stress induces selective and long-lasting inflammatory response evoked by changes in corticosterone accumulation and signaling in rat hippocampus. Metab Brain Dis. 2016 Apr; 31 (2): 445–54. DOI: 10.1007/s11011-015-9785-7.
  5. Uzakov SS, Ivanov AD, Salozhin SV, Markevich VA, Gulyaeva NV. Lentiviral-mediated overexpression of nerve growth factor (NGF) prevents beta-amyloid [25-35]-induced long term potentiation (LTP) decline in the rat hippocampus. Brain Res. 2015 Oct 22; 1624: 398–404. DOI: 10.1016/j.brainres.2015.07.051.
  6. Gulyaeva NV. Brain ischemia, endoplasmic reticulum stress, and astroglial activation: new insights. J Neurochem. 2015 Feb; 132 (3): 263–5. DOI: 10.1111/jnc.13016.
  7. Peregud DI, Panchenko LF, Gulyaeva NV. Elevation of BDNF exon I-specific transcripts in the frontal cortex and midbrain of rat during spontaneous morphine withdrawal is accompanied by enhanced pCreb1 occupancy at the corresponding promoter. Neurochem Res. 2015 Jan; 40 (1): 130–8. DOI: 10.1007/s11064-014-1476-y.
  8. Stepanichev M, Dygalo NN, Grigoryan G, Shishkina GT, Gulyaeva N. Rodent models of depression: neurotrophic and neuroinflammatory biomarkers. Biomed Res Int. 2014; 2014: 932757. DOI: 10.1155/2014/932757. Review.
  9. Tishkina A, Rukhlenko A, Stepanichev M, Levshina I, Pasikova N, Onufriev M, Moiseeva Y, Piskunov A, Gulyaeva N. Region-specific changes in activities of cell death-related proteases and nitric oxide metabolism in rat brain in a chronic unpredictable stress model. Metab Brain Dis. 2012 Dec; 27 (4): 431–41. DOI: 10.1007/s11011-012-9328-4.
  10. Aniol VA, Ivanova-Dyatlova AY, Keren O, Guekht AB, Sarne Y, Gulyaeva NV. A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats. Epilepsy Behav. 2013 Feb; 26 (2): 196–202. DOI: 10.1016/j.yebeh.2012.12.006.