ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
REVIEW
Alternatives to antibiotics: phage lytic enzymes and phage therapy
About authors
Belozersky Institute of Physico-Chemical Biology,Lomonosov Moscow State University, Moscow, Russia
Correspondence should be addressed: Pavel Nazarov
ul. Narimanovskaya 22, k,3, kv. 294, Moscow, 117997; moc.liamg@apvorazan
About paper
Funding: this work was supported by the Russian Science Foundation (Grant ID 14-50-00029).
Acknowledgements: the author wishes to thank the researchers from the Laboratory of Membrane Biophysics (Department of Bioenergetics, Belozersky Institute of Physico-Chemical Biology), the Laboratory of Molecular Bioengineering (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry) and the Laboratory of Bacteriophage Genetics (Mechnikov Research Institute of Vaccines and Sera) for discussing with him some aspects of the use of bacteriophages, phage lysins and antibacterial photodynamic therapy.
Received: 2018-01-23
Accepted: 2018-01-28
Published online: 2018-03-05
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Multiple drug resistance of nosocomial bacterial strains provoked by the unwise and uncontrolled use of antibiotics in medicine and agriculture seriously threatens modern healthcare: minor and trivial infections are about to kill again. A solution may lie in the development of new alternatives to antibiotics. This review highlights the most interesting approaches to the development of antibacterial drugs focusing on the most promising ones, such as phage therapy and phage lytic enzymes (lysins).
Keywords: antibiotic, bacterophage, phage lysin, phage therapy, antibiotic treatment, multiple drug resistance