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Combination laser therapy for epiretinal membrane: a physico-mathematical model

About authors

1 Pirogov Russian National Research Medical University, Moscow, Russia

2 Research Center for Ophthalmology, Pirogov Russian National Research Medical University, Moscow, Russia

3 Department of Ophthalmology, Faculty of Pediatrics, Pirogov Russian National Research Medical University, Moscow, Russia

4 Stepanov Institute of Physics, Minsk, Belarus

Correspondence should be addressed: Ekaterina P. Tebina
Volokolamskoe shosse 30, bl. 2, 123182; ur.liam@anibetaniretake

About paper

Author contribution: Takhchidi KP and Kachalina GF conceived and designed the study; Tebina EP collected and analyzed the data; Kasminina TA performed laser therapy; Zheltov GI, Kasminina TA, and Tebina EP wrote the manuscript; Zheltov GI and Takhchidi KP revised the manuscript.

Received: 2019-03-01 Accepted: 2019-03-15 Published online: 2019-04-30
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An epiretinal membrane (ERM) is a product of abnormal cell proliferation on the inner surface of the retina and at the vitreomacular interface. Laser therapy is an interesting modality for treating pathologies of the vitreomacular interface. The wise choice of laser settings (wavelength, exposure time, power) minimizes damage to the retina and ensures a good therapeutic effect. This could be a serious impetus to the development and refinement of laser technologies for treating ERM. This work investigates the biophysical response of structural retinal components, including the dynamics of temperatures and acoustic oscillations, protein denaturation, and stimulation of tissue regeneration, to a quasi-cw laser beam and a subsequent series of laser micropulses. The manuscript also analyzes the mechanisms underlying the therapeutic effect of the proposed laser therapy in patients with ERM.

Keywords: optical coherence tomography, epiretinal membrane, subthreshold micropulse laser photocoagulation, combination laser therapy

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