Sergey A. MOSHKOVSKII
Head of the Department of Personalized Medicine,
Institute of Biomedical Chemistry (Moscow, Russia)
Head of the Department of Biochemistry, Biomedical Faculty,
Pirogov Russian National Research Medical University (Moscow, Russia)
DSc (biology), professor
Areas of expertise:
postgenomic technologies, molecular biomarkers for malignant tumors, proteomics, proteogenomics, metabolomics, human proteome, mass spectrometry in biology and medicine
Twenty years ago two life sciences, biology and medicine, were isolated from each other and relied on their own specific tools. Physiology was isolated from biochemistry; biophysics and molecular biology did not have much in common. The invention, of Internet, increased rates and improved performance of molecular technologies resulted in the fusion of stand-alone sciences. Now all significant research is complex and comprehensive in terms of its methodology and objects. Biomedicine can be depicted as a graph whose faces represent a combination of different methods and systems. By saying that I mean that a modern researcher must be broadminded and bear in mind various aspects of many different fields, from zoology to nuclear physics, no matter how difficult it is. Unlike business, science is based on cooperation more than competition. The idea of open databases very much agrees with this statement. In genomics, propeomics and other -omics I have been dealing with, extensive data sharing has become common and is a requirement for serious publications. Compete but do not forget to cooperate. And remember that biology has started in nature.
- Lobas AA, Karpov DS, Kopylov AT, Solovyeva EM, Ivanov MV, Ilina IY, Lazarev VN, Kuznetsova KG, Ilgisonis EV, Zgoda VG, Gorshkov MV, Moshkovskii SA. Exome-based proteogenomics of HEK-293 human cell line: Coding genomic variants identified at the level of shotgun proteome. Proteomics. 2016; 16 (14): 1980–91.
- Kliuchnikova AA, Samokhina NI, Ilina IY, Karpov DS, Pyatnitskiy MA, Kuznetsova KG, Toropygin IY, Kochergin SA, Alekseev IB, Zgoda VG, Archakov AI, Moshkovskii SA. Human aqueous humor proteome in cataract, glaucoma, and pseudoexfoliation syndrome. Proteomics. 2016; 16 (13): 1938–46.
- Kuznetsova KG, Trufanov PV, Moysa AA, Pyatnitskiy MA, Zgoda VG, Gorshkov MV, Moshkovskii SA. Threonine versus isothreonine in synthetic peptides analyzed by high-resolution liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2016; 30 (11): 1323–31.
- Pyatnitskiy M, Karpov D, Poverennaya E, Lisitsa A, Moshkovskii S. Bringing Down Cancer Aircraft: Searching for Essential Hypomutated Proteins in Skin Melanoma. PLoS One. 2015; 10 (11): e0142819.
- Polyakova A, Kuznetsova K, Moshkovskii S. Proteogenomics meets cancer immunology: mass spectrometric discovery and analysis of neoantigens. Expert Rev Proteomics. 2015; 12 (5): 533–41.
- Chernobrovkin AL, Kopylov AT, Zgoda VG, Moysa AA, Pyatnitskiy MA, Kuznetsova KG, Ilina IY, Karpova MA, Karpov DS, Veselovsky AV, Ivanov MV, Gorshkov MV, Archakov AI, Moshkovskii SA. Methionine to isothreonine conversion as a source of false discovery identifications of genetically encoded variants in proteogenomics. J Proteomics. 2015; 120: 169–78.
- Karpova MA, Karpov DS, Ivanov MV, Pyatnitskiy MA, Chernobrovkin AL, Lobas AA, Lisitsa AV, Archakov AI, Gorshkov MV, Moshkovskii SA. Exome-driven characterization of the cancer cell lines at the proteome level: the NCI-60 case study. J Proteome Res. 2014; 13 (12): 5551–60.