ISSN Print 2500–1094    ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

Andrey V. GUDKOV

Senior Vice President for Basic Research,
Chair of the Department of Cell Stress Biology,
Roswell Park Cancer Institute (Buffalo, New York, USA)

PhD (oncology), DSc (biology)

Areas of expertise:

new principles, drugs and targets for the prevention and treatment of cancer; molecular and cellular targets and drugs in anti-aging medicine; origin and control of retroelements, their role in evolution and currently existing pathologies

Special awards and honors:

University Scholar, University of Illinois at Chicago (1999)
P. K. Ranney Foundation Award, Cleveland Clinic Foundation (2005)
Garman Family Chair in Cell Stress Biology, Roswell Park Cancer Institute (2008)
Thomas Tomasi Hope Award, Roswell Park Cancer Institute (2016)

ABOUT SCIENCE:

Significant publications in last 5 years

  1. Hall BM, Balan V, Gleiberman AS, Strom E, Krasnov P, Virtuoso LP, Rydkina E, Vujcic S, Balan K, Gitlin I, Leonova K, Polinsky A, Chernova OB, Gudkov AV. Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells. Aging (Albany NY). 2016; 8 (7): 1294–315.
  2. Komarov AP, Komarova EA, Green K, Novototskaya LR, Baker PS, Eroshkin A, Osterman AL, Chenchick AA, Frangou C, Gudkov AV. Functional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure. Cell Death Dis. 2016; 7: e2145.
  3. Brackett CM, Kojouharov B, Veith J, Greene KF, Burdelya LG, Gollnick SO, Abrams SI, Gudkov AV. Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis. PNAS. 2016 Feb 16; 113 (7): E874–83.
  4. Krivokrysenko VI, Toshkov I, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra R, Narizhneva N, Singh VK, Whitnall M, Purmal A, Shakhov A, Gudkov AV, and Feinstein E. TLR5 Agonist Entolimod Mitigates Acute Radiation Syndrome in Non-human Primates. PLoS One. 2015; 10 (9): e0135388.
  5. Natarajan V, Komarov AP, Ippolito T, Bonneau K, Chenchik AA, Gudkov AV. Peptides genetically selected for NF-kB activation cooperate with oncogene Ras and model carcinogenic role of inflammation. PNAS. 2014; 111 (4): E474–83.
  6. Burdelya LG, Brackett CM, Kojouharov B, Gitlin II, Leonova K, Gleiberman AS, Aygun-Sunar S, Veith J, Johnson C, Haderski GJ, Stanhope-Baker P, Allamaneni S, Skitzki J, Zeng M, Martsen E, Medvedev A, Scheblyakov D, Artemicheva NM, Logunov DY, Gintsburg AL, Naroditsky BS, Makarov SS, Gudkov AV. Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonists. PNAS. 2013; 110 (20): E1857–66.
  7. Leonova KI, Brodsky L, Lipchick B, Pal M, Novototskaya L, Chenchik AA, Sen GC, Komarova EA, Gudkov AV. p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs. PNAS. 2013; 110 (1): E89–98.
  8. Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, Seluanov A. Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. PNAS. 2012; 109 (47): 19392–6.
  9. Spengler ML, Kuropatwinski KK, Comas-Soberats M, Gasparian AV, Fedtsova N, Gleiberman AS, Gitlin II, Artemicheva NM, Deluca KA, Gudkov AV, Antoch MP. Core circadian protein CLOCK is a positive regulator of NF-kB-mediated transcription. PNAS. 2012; 109 (37): E2457–65.
  10. Yoon S-I, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA. Structural Basis of TLR5-Flagellin Recognition and Signaling. Science. 2012; 335 (6070): 859–64.