Natalia V. GULYAEVA
Vice President for Research,
Head of the Laboratory of Functional Biochemistry of the Nervous System,
Institute of Higher Nervous Activity and Neurophysiology (Moscow, Russia)
DSc (biology), professor
Areas of expertise:
neurobiology (neurophysiology and pathology of the brain, neurochemistry, molecular mechanisms of neural plasticity and pathology, mechanisms of stress resistance and stress reactivity); translational medicine (modeling of neurological and psychiatric disorders in parallel with neurochemical studies of epilepsy, stroke, depression, anxiety, and neurodegenerative disorders in the clinical setting)
I got into neurobiology almost accidentally — at least I thought so at that time. I no longer see it as an accident now. After I graduated from the Faculty of Biology and completed my postgraduate course at the Department of Biochemistry of MSU, I got a position at the Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences where I have been working ever since. I have come to realize that the brain is an absolutely fascinating thing that cannot be fully cognizable and therefore remains a permanent attraction for scientists and a perpetuum mobile of scientific research. What is the secret to brain plasticity? What are the mechanisms of its amazing adaptivity? What breaks in the brain of patients with neurological and mental disorders? To what extent can we model those “breakages”? What can be studied in the clinical setting? How can we bring experiments into the clinical setting and verify their results with our clinical findings to better understand the underlying mechanisms of various pathologies. Our research area is very interesting and holds promise for discoveries that will definitely be useful even in the long run. Tremendous work that has been carried out in this area worldwide is already yielding the first results: we start to understand the mechanisms of a number of cerebral pathologies and can elaborate approaches to their treatment. What is also important is that neurobiology and translational medicine have something for everyone, be it a biologist, a chemist, a physicist or a doctor. The more diverse is a team, the more effectively they work, because team members share their opinions and knowledge and learn to use different technologies, gaining new experience and thus ensuring success of interdisciplinary research.
- Peregud DI, Yakovlev AA, Stepanichev MY, Onufriev MV, Panchenko LF, Gulyaeva NV. Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent. Cell Mol Neurobiol. 2016 Aug; 36 (6): 839–49. DOI: 10.1007/s10571-015-0267-6.
- Fominykh V, Onufriev MV, Vorobyeva A, Brylev L, Yakovlev AA, Zakharova MN, Gulyaeva NV. Increased S-nitrosothiols are associated with spinal cord injury in multiple sclerosis. J Clin Neurosci. 2016 Jun; 28: 38–42. DOI: 10.1016/j.jocn.2015.09.017.
- Tishkina A, Stepanichev M, Kudryashova I, Freiman S, Onufriev M, Lazareva N, Gulyaeva N. Neonatal proinflammatory challenge in male Wistar rats: Effects on behavior, synaptic plasticity, and adrenocortical stress response. Behav Brain Res. 2016 May 1; 304: 1–10. DOI: 10.1016/j.bbr.2016.02.001.
- Piskunov A, Stepanichev M, Tishkina A, Novikova M, Levshina I, Gulyaeva N. Chronic combined stress induces selective and long-lasting inflammatory response evoked by changes in corticosterone accumulation and signaling in rat hippocampus. Metab Brain Dis. 2016 Apr; 31 (2): 445–54. DOI: 10.1007/s11011-015-9785-7.
- Uzakov SS, Ivanov AD, Salozhin SV, Markevich VA, Gulyaeva NV. Lentiviral-mediated overexpression of nerve growth factor (NGF) prevents beta-amyloid [25-35]-induced long term potentiation (LTP) decline in the rat hippocampus. Brain Res. 2015 Oct 22; 1624: 398–404. DOI: 10.1016/j.brainres.2015.07.051.
- Gulyaeva NV. Brain ischemia, endoplasmic reticulum stress, and astroglial activation: new insights. J Neurochem. 2015 Feb; 132 (3): 263–5. DOI: 10.1111/jnc.13016.
- Peregud DI, Panchenko LF, Gulyaeva NV. Elevation of BDNF exon I-specific transcripts in the frontal cortex and midbrain of rat during spontaneous morphine withdrawal is accompanied by enhanced pCreb1 occupancy at the corresponding promoter. Neurochem Res. 2015 Jan; 40 (1): 130–8. DOI: 10.1007/s11064-014-1476-y.
- Stepanichev M, Dygalo NN, Grigoryan G, Shishkina GT, Gulyaeva N. Rodent models of depression: neurotrophic and neuroinflammatory biomarkers. Biomed Res Int. 2014; 2014: 932757. DOI: 10.1155/2014/932757. Review.
- Tishkina A, Rukhlenko A, Stepanichev M, Levshina I, Pasikova N, Onufriev M, Moiseeva Y, Piskunov A, Gulyaeva N. Region-specific changes in activities of cell death-related proteases and nitric oxide metabolism in rat brain in a chronic unpredictable stress model. Metab Brain Dis. 2012 Dec; 27 (4): 431–41. DOI: 10.1007/s11011-012-9328-4.
- Aniol VA, Ivanova-Dyatlova AY, Keren O, Guekht AB, Sarne Y, Gulyaeva NV. A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats. Epilepsy Behav. 2013 Feb; 26 (2): 196–202. DOI: 10.1016/j.yebeh.2012.12.006.