Bulletin of RSMU
ISSN Print 2500–1094
ISSN Online 2542–1204


Vice President for Research,
Head of the Laboratory of Functional Biochemistry of the Nervous System,
Institute of Higher Nervous Activity and Neurophysiology (Moscow, Russia)

DSc (biology), professor

Areas of expertise:

neurobiology (neurophysiology and pathology of the brain, neurochemistry, molecular mechanisms of neural plasticity and pathology, mechanisms of stress resistance and stress reactivity); translational medicine (modeling of neurological and psychiatric disorders in parallel with neurochemical studies of epilepsy, stroke, depression, anxiety, and neurodegenerative disorders in the clinical setting)


Significant publications in last 5 years

  1. Peregud DI, Yakovlev AA, Stepanichev MY, Onufriev MV, Panchenko LF, Gulyaeva NVExpression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent. Cell Mol Neurobiol. 2016 Aug; 36 (6): 839–49. DOI: 10.1007/s10571-015-0267-6.
  2. Fominykh V, Onufriev MV, Vorobyeva A, Brylev L, Yakovlev AA, Zakharova MN, Gulyaeva NVIncreased S-nitrosothiols are associated with spinal cord injury in multiple sclerosis. J Clin Neurosci. 2016 Jun; 28: 38–42. DOI: 10.1016/j.jocn.2015.09.017.
  3. Tishkina A, Stepanichev M, Kudryashova I, Freiman S, Onufriev M, Lazareva N, Gulyaeva NNeonatal proinflammatory challenge in male Wistar rats: Effects on behavior, synaptic plasticity, and adrenocortical stress response. Behav Brain Res. 2016 May 1; 304: 1–10. DOI: 10.1016/j.bbr.2016.02.001.
  4. Piskunov A, Stepanichev M, Tishkina A, Novikova M, Levshina I, Gulyaeva NChronic combined stress induces selective and long-lasting inflammatory response evoked by changes in corticosterone accumulation and signaling in rat hippocampus. Metab Brain Dis. 2016 Apr; 31 (2): 445–54. DOI: 10.1007/s11011-015-9785-7.
  5. Uzakov SS, Ivanov AD, Salozhin SV, Markevich VA, Gulyaeva NVLentiviral-mediated overexpression of nerve growth factor (NGF) prevents beta-amyloid [25-35]-induced long term potentiation (LTP) decline in the rat hippocampus. Brain Res. 2015 Oct 22; 1624: 398–404. DOI: 10.1016/j.brainres.2015.07.051.
  6. Gulyaeva NVBrain ischemia, endoplasmic reticulum stress, and astroglial activation: new insights. J Neurochem. 2015 Feb; 132 (3): 263–5. DOI: 10.1111/jnc.13016.
  7. Peregud DI, Panchenko LF, Gulyaeva NVElevation of BDNF exon I-specific transcripts in the frontal cortex and midbrain of rat during spontaneous morphine withdrawal is accompanied by enhanced pCreb1 occupancy at the corresponding promoter. Neurochem Res. 2015 Jan; 40 (1): 130–8. DOI: 10.1007/s11064-014-1476-y.
  8. Stepanichev M, Dygalo NN, Grigoryan G, Shishkina GT, Gulyaeva NRodent models of depression: neurotrophic and neuroinflammatory biomarkers. Biomed Res Int. 2014; 2014: 932757. DOI: 10.1155/2014/932757. Review.
  9. Tishkina A, Rukhlenko A, Stepanichev M, Levshina I, Pasikova N, Onufriev M, Moiseeva Y, Piskunov A, Gulyaeva NRegion-specific changes in activities of cell death-related proteases and nitric oxide metabolism in rat brain in a chronic unpredictable stress model. Metab Brain Dis. 2012 Dec; 27 (4): 431–41. DOI: 10.1007/s11011-012-9328-4.
  10. Aniol VA, Ivanova-Dyatlova AY, Keren O, Guekht AB, Sarne Y, Gulyaeva NVA single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats. Epilepsy Behav. 2013 Feb; 26 (2): 196–202. DOI: 10.1016/j.yebeh.2012.12.006.