Published online: 2018-06-22
DOI: 10.24075/brsmu.2018.018
Traditionally, anti-age therapies employ ultraviolet radiation and exposure to ozone, nitric oxide and electromagnetic fields. Non-thermal atmospheric-pressure plasma (NTAPP) combines the effects of all those techniques. The aim of our study was to assess the feasibility of low-dose NTAPP application in anti-age facial skin therapy. Ten female patients aged 50 to 55 years were examined and three facial zones were chosen for the experiment: the T-zone (the central part of the forehead) and the “crow’s feet” areas on the right and left sides of the face. Ultrasonography was performed on the DUB SkinScaner before the treatment course and 24 hours after the last treatment. Cleansed skin was exposed to a low-energy NTAPP helium jet generated by the HELIOS system (Plasma Research and Production, Russia). Exposure time was 5 min per zone. Each participant received 10 NTAPP procedures on alternate days. Before therapy, the skin condition in all participants fitted into morphotype 3. Ultrasonography of the studied zones revealed a considerable deformation of the skin surface, a thickening of the epidermis with a distinct border between the epidermis and the dermis, a slight thinning of the dermis, its relatively homogenous echogenicity, and a blurred border between the dermis and the hypodermis. After the course was completed, all patients demonstrated an evener skin surface, reduced epidermal thickness and reduced acoustic density of the epidermis and the dermis; the dermis tended to have above average thickness. The most significant changes were observed for the wrinkles: they became less pronounced in the “crow’s feet” area. Exposure to NTAPP caused the epidermal corneum to diminish in thickness; it also stimulated microcirculation and improved the condition of the hydrolipidic film, all of which ultimately led to the effacement of wrinkles. Treatment produced no adverse effects on the skin or its appendages.
Published online: 2018-06-16
DOI: 10.24075/brsmu.2018.017
The health of the cervical spine (CS) and the functional state of the pectoral girdle are interdependent. Injuries to the pectoral girdle can be an underlying cause of CS pain, including cervicalgia. The aim of this study was to evaluate the condition of the cervical spine in patients with cervicalgia developed after a pectoral girdle injury using radiographic and physical examinations. The study included 400 patients complaining of cervicalgia. Pain intensity was evaluated on the visual analog scale (VAS); the impact of the condition on patients’ lives was assessed using the Neck Disability Index (Russian language). During physical examinations, the general health of the spine was evaluated and abnormalities in the cervical spine were noted. All participants underwent a radiographic scan of the cervical spine in the lateral and anterior-posterior projections; 49.5% of patients underwent postural digital radiography to evaluate their CS sagittal profile. All patients received an MRI scan. Based on the results, we identified certain functional changes in the cervical spine which possibly caused cervicalgia. Structurally and functionally, the changes were divided into static and dynamic. We conclude that cervical spinal pain is a common problem among patientswith previous pectoral girdle injury.
Published online: 2018-06-08
DOI: 10.24075/brsmu.2018.016
CRISPR-Сas systems are widespread in bacteria and archaea. They provide adaptive immunity against bacterial phages and plasmids and exert a few important functions like regulation of gene expression, DNA repair or virulence formation. We have analyzed the CRISPR-Cas systems of 7 M. tuberculosis lineages with fully sequenced genomes, namely Beijing, B0/W-148, EAI, Haarlem, Ural, LAM, and S. The CRISPR-Cas systems present in the analyzed genomes belong to type III-A. M. tuberculosis lineages differ in their CRISPR-Cas structure; in the Beijing lineage a part of the system is reduced. We have conducted a search for the functionally related partners and compensatory mechanisms of cas-genes using a method of phylogenetic profiling. The obtained phylogenetic profiles show that some genes have undergone similar evolutionary events. The reduction of the system’s part in the Beijing lineage was accompanied by at least two evolutionary losses and one acquisition of genome regions. Exploration of alternative CRISPR-Cas functions in M. tuberculosis and their possible associations with other gene systems remains an exciting challenge.


Published online: 2018-02-16
DOI: 10.24075/brsmu.2018.001
Recent studies of T-cell clonal repertoires of patients with ankylosing spondylitis (AS) have led to the discovery of AS-associated T-cell clones with a highly homologous T-cell receptor structure. The role of T-lymphocytes in the disease progression cannot be elucidated without analyzing the diversity and abundance of functionally different T-cell clones found in patients with AS. Using a state-of-the-art technique for T-cell repertoire profiling based on massively parallel sequencing, we, for the first time, studied the T-cell receptor repertoire of activated T-cells from the peripheral blood of a patient with AS. We have demonstrated that a subpopulation of CD38+HLA-DR+ T-lymphocytes is highly diverse both in terms of clonal diversity and abundance of the identified clonotypes, suggesting diverse antigen specificity of the activated peripheral blood T-cells. Most of the activated T-cell clonotypes had low abundance in total population of peripheral blood T-cells. In the repertoire of activated T-cells we have found the clonotype TRBV9_CASSVGVYSTDTQYF_TRBJ2-3, previously discovered in AS and reactive arthritis, and a few other clonotypes of cytotoxic and helper T-cells that may have a role in promoting inflammation in AS patients. Presence of the AS-associated clonotype in activated T-cell subset suggests that the T-cells might play an active role in ongoing inflammation during the disease progression. This provides rationale for further research of their antigen specificity and role in triggering or maintaining AS.
Dear researcher!
At the end of 2015, Bulletin of RSMU saw an important change in its typographic design and content. We formulated new editorial policies and established strict ethical standards for submitted manuscripts in accordance with the guidelines of reputable international bodies. As a result, about a quarter of the submitted works have been rejected, the primary reason being the author trying to submit a previously published article. Sometimes authors believe that by making slight changes to the introduction, excluding a few people from the study, performing a new statistical analysis, and thus obtaining totally new results they will turn their old manuscript into a novel work. That is why we would like to talk about scientific integrity, honesty, plagiarism, and self-plagiarism in our special project “Author’s work”.
Richard FEYNMAN Cargo cult science
American physicist Richard P. Feynman, a Nobel laureate, was always very scrupulous about the quality of a research study. During his commencement address at the California Institute of Technology in 1974, he talked about scientific integrity and honesty and warned young researchers “not to fool” themselves. A must-read for anyone who believes he/she is a true scientist.
Ivan PAVLOV On the Russian mind
In 1918, Russian physiologist Ivan Pavlov, a Nobel laureate, delivered two lectures: on the mind in general and the Russian mind in particular; on those mind qualities that determine the success of a research work and on how these qualities are present in the Russian mind. Pavlov's thoughts are an effective vaccine against poor intellectual work.
2018-01-25 OUR NEWS
Publishing fee

Since 2018 the journal "Bulletin of RSMU" publishes manuscripts in which financial support for the research is declared, on a fee basis. Regardless of the source of funding, the type of paper and the volume of the text, the publishing fee is 30 thousand rubles. We want to emphasize that we are not talking about advertising publications — we do not publish advertisements. At the same time we are sure that modern science develops much more effectively if access to new research data is free. The journal will continue to work in the open-access format.

2018-01-24 OUR NEWS
We use DOI!

DOI (Digital Object Identifier) is an important tool for organizing the storage of scientific texts. Assigning scientific books or publications with DOIs makes their search much easier for researchers around the world. "Bulletin of RSMU" gave DOIs to all papers published in both language versions of the journal in 2016–2017. We see the first results: regular reports from CrossRef (an international agency that organizes work with identifiers) show that some papers of the authors of the "Bulletin of RSMU" already has several tens of views thanks to DOIs.