ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Features of С-Reactive Protein and Cytokine Activity Dynamics in Patients with Myocardial Infarction and Its Effect on the Outcome and Prognosis for the Disease
About authors
1 Department of Outpatient Therapy No. 2, Medical Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
2 Municipal Clinical Hospital No. 13, Moscow, Russia
Correspondence should be addressed: Irina Chukaeva
ul. Velozavodskaya, d. 1/1, Moscow, Russia,115280; сur.liam@aveakuh
Received: 2013-02-25
Accepted: 2013-04-25
Published online: 2017-01-05
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Imbalance of inflammatory reactants in acute myocardial infarction causes inadequate processes of necrosis, destruction and repair, and can affect the course and prognosis of the disease. In this study the dynamics of C-reactive protein and cytokines (IFN-γ, IL-4, IL-6, IL-8 and IL-10) in patients with myocardial infarction was investigated. It was found that levels and dynamics of C-reactive protein and cytokines may predict the disease, as well as its immediate and long-term prognosis. A significant increase in the concentrations of CRP, IL-8, IL-10, IL-4, INF-γ, IL-6 in the first day of the disease was revealed in patients with complications of myocardial infarction. Excessively low values of INF-γ and IL-6 are associated with poor long-term outcomes up to the lethal.
Keywords: inflammation, myocardial infarction, C-reactive protein, cytokine dynamics, prognosis of the disease