ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Disbiotic Disturbance of Biocenosis in Oropharynx and its Role in Etiopathogenesis of Infectious Mononucleosis
About authors
1 Department oflnfectious Diseases in Children No. 1, Pediatric Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
2 Department oflnfectious Diseases in Children No. 2, Pediatric Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
3 Department of Skin Diseases and Cosmetology, Doctors’ Improvement Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
4 Department of Laboratory Diagnostics,
N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow, Russia
Correspondence should be addressed: Olga Shamsheva
4-y Dobryininskiy pereulok, d. 1, Moscow, Russia, 117049; ur.liam@noitcefni-hc
Received: 2013-03-20
Accepted: 2013-09-04
Published online: 2017-01-05
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Mass spectrometry of microbial markers was used to study the microbial landscape of the oropharynx in 22 children with infectious mononucleosis aged from 3 to 14 years. The comparison group consisted of 10 children without clinical signs of infectious mononucleosis and acute respiratory viral infections including mucosal and tonsils hyperemia. The data obtained helped to verify and quantify the composition of the microbial community in the oropharynx in infectious mononucleosis and treat angina in infectious mononucleosis as a disease with the association of various opportunistic pathogens that exceeded the number of microbes in healthy children at least more than twice.
Keywords: infectious mononucleosis, microbiocenosis, mass spectrometry, microbial markers, mucous membranes of oropharynx