BIOMEDICAL JOURNAL OF PIROGOV RNRMU (MOSCOW, RUSSIA)
Issue 6, 2018
Nanotechnology is an integral part of our life. Both in the form of products with fundamentally new properties, and in the form of new names: from nano-laboratories to RUSNANO. And in order not to deviate from the mainstream and keep up with the trends, we also decided to release an issue with the trendy prefix: NANOMEDICINE. This is not just some kind of "very very small medicine." Contrarily it is a very large medicine, this is the future of clinical approaches in the treatment of oncological diseases, targeted delivery of pharmaceuticals, non-invasive therapy, etc. The last issue of 2018 is devoted to various nanotechnological approaches in medicine.
Issue 1, 2018For almost 100 years now, mankind has been fighting incessantly against pathogenic bacteria with the help of more and more new antibiotics. But evolutionary flexibility allows pathogens to bypass our locks almost at the speed of the invention. One of the good alternatives to speeding up and reducing the cost of this arms race is the bacteriophage.
Issue 2, 2018
Сomplex genomes editing with CRISPR-Cas systems is the most promising approach to introduce exact changes in DNA in vivo, both in scientific applications and in medicine. The diversity of CRISPR-Cas systems (protecting the bacterium from a virus attack) allowed researchers to deduce a wide range of enzymes with various properties for the lab applications. However, the new genome editing systems investigation is unstoppable and in the near future we will see CRISPR-Cas systems with new characteristics of efficiency and accuracy.
Issue 3, 2018
The long-term use of a wide range of antibiotics led to the appearance of drug-resistant and highly virulent strains of Mycobacterium tuberculosis. The effectiveness of treatment of such forms with multiple and broad drug resistance depends not only on the use of new drugs, but also on the patient's immune status and the composition of its microbiota. In this regard, the development of vaccines, adjuvants and probiotics with selective immunomodulating and antioxidant properties is gaining new importance.
Issue 4, 2018
The lack of a unified biohazard monitoring center is a factor of society vulnerability. The national biohazard monitoring system could be the basis for the nationwide biosecurity service and at the same time a means of identifying and addressing its own vulnerabilities. The topic publications describe the elements of a national system for biological threats monitoring, pointing out the features of the operation of equipment during practical trials.
Issue 5, 2018
One of the key components of 4P medicine is prevention of the onset of the disease. Preventive medicine is the most important direction of health care, designed to eliminate the risk factors for the occurrence of diseases at all stages of our development: from zygotes to the elderly, as well as at all levels of our existence: from genetic to social. This issue presents a study of the impact of various factors on our health, and suggests specific measures for the prevention and active introduction of positive factors into everyday life. Special attention is paid to the role of the environment, living conditions, food and water supply.