BIOMEDICAL JOURNAL OF PIROGOV RNRMU (MOSCOW, RUSSIA)
Issue 5, 2019
A gradual understanding of the processes of tumor formation at the cellular and molecular level provides new tools to fight cancer. Today, methods of “attracting attention” of the immune system to tumor cells come to the fore. Immunooncology is a branch of medicine whose therapeutic focus is immunotherapy of tumors. In particular, adoptive immunotherapy using genetically modified autologous T-lymphocytes with an artificial receptor of a given specificity (CAR-therapy). A review of this issue is devoted to existing genetic engineering approaches to tumor immunotherapy.
Issue 6, 2018
Nanotechnology is an integral part of our life. Both in the form of products with fundamentally new properties, and in the form of new names: from nano-laboratories to RUSNANO. And in order not to deviate from the mainstream and keep up with the trends, we also decided to release an issue with the trendy prefix: NANOMEDICINE. This is not just some kind of "very very small medicine." Contrarily it is a very large medicine, this is the future of clinical approaches in the treatment of oncological diseases, targeted delivery of pharmaceuticals, non-invasive therapy, etc. The last issue of 2018 is devoted to various nanotechnological approaches in medicine.
Issue 1, 2019
Laboratory tests - perhaps the fastest growing field in medicine. Without a diverse biochemical, immunological, molecular genetic and other laboratory studies today, almost no diagnosis is made. Medicine becomes "precision", seeking to develop accurate quantitative characteristics of various states of our body. The issue is devoted to the use of clinical laboratory diagnostic methods in modern 5P medicine.
Issue 2, 2019
Cancer becomes a scourge of rapidly aging humanity. The evolution of Homo sapiens didn't expect such a high lifetime. As a result, there is a lack of natural (evolutionary) mechanisms for dealing with crazy asocial tumor cells. And here, as in many other human activities, we interfere with the cellular ecosystem, trying to manually patch the evolutionary gaps. Targeted therapy is a dope for the immune system, allowing it to attack an asocial element with new forces. This is a precision weapon, acting only on certain types of cells. Perhaps it is the targeted drugs that will allow us not to die from cancer after we learn how to stop the aging program.
Issue 3, 2019
At all times, people wanted to have as healthy offspring as possible. But in different eras different actions were taken for this. The Celts of Gaul made human sacrifices for the sake of better offspring. Orthodox prayed Matrona, pregnant women smeared the belly with church oil, in order to safely endure and give birth to a healthy baby. Today, in addition to these traditional approaches, science can offer methods for prenatal molecular genetic screening based on the analysis of extracellular DNA circulating in the blood of a pregnant woman.
Issue 4, 2019
Over the past 10 years, exosomes have moved from the category of exotic and obscure vesicles to the hype topic of the most promising studies. Mention of the term “exosomes” in pub-med has grown from 150 (in 2009) to almost 2000 (in 2019). More and more new works are appearing on the use of exosomes in models of various diseases as both diagnostic and therapeutic agents. Interest in exosomes is determined by their complex composition, the possibility of isolation, and, apparently, targeted action on certain types of cells. The title article of the issue describes the possibility of using exosomes in Duchenne myodystrophy models.