Miscarriage still occupies a leading place among the main problems of medicine. In recent decades, special attention is paid to the system of genetic predictors of miscarriage. Special ferments are responsible for catecholamines exchange in the body, one of which is the catechol-o-methyltransferase, functional activity of which is genetically determined. DNA excision reparation system with the participation of the enzyme 8-oxoguanine-DNA glycosylase maintains the original structure of DNA, which is very important for the homeostasis of the organism. In our study we conducted genotyping of 274 patients for the presence of polymorphism of rs4680 gene COMT and polymorphism of rs1052133 gene OGG1 and determined their impact on the course of pregnancy. It was found that carriage of A/A and G/A rs4680 genotypes of COMT gene and G/G and C/G rs1052133 genotypes of OGG1 gene was associated with an increased risk of miscarriage.