The study evaluated clinical efficacy and safety of the use of cells antitumor immunotherapy methods — vaccines based on autologic dendritic and allogenic LAK-cells in combination with recombinant interleukin-2 (IL-2). The clinical study involved cancer patients with skin melanoma of grades III-IV and patients with metastatic effusions resistant to systemic chemotherapy. The data led to the conclusion of safety, immune competence and reasonable effectiveness of DC-based vaccines in therapeutic and prophylactic schemes in patients with skin melanoma. The results showed that intra-cavity IL-2/LAK-immunotherapy was highly effective and well tolerated in treatment of patients with metastatic effusions.