Depending on the insertion-deletion polymorphism of the angiotensin-converting enzyme and Hindlll DNA polymorphism of lipoprotein lipase gene there were studied the clinical course of coronary heart disease and five-year survival of patients after an exacerbation of the disease. It was found that the most important genetic predictors of short- and long-term adverse outcomes of acute ischemic heart disease are the genotype H+H+ of lipoprotein lipase gene, DD genotype of the angiotensin-converting enzyme gene and the combination of these genotypes.