This article presents the analysis of long-term results of therapy of adolescents (n = 48; median age — 16.6 years; minimum and maximum age — 15.0 and 18.1) and young adults (n = 49; median age — 21.0 years; minimum and maximum age — 18.5 and 33.6) with primary Hodgkin's lymphoma (HL). During 1997–2008 all the patients were treated according to the pediatric protocol DAL-HD-90. Twelve-year event-free survival was 73.4 ± 4.8 % and overall survival — 81.5 ± 4.7 % for all patients. Twelve-year event-free survival for adolescents at the early stages of HL was documented at the level of 83.3 ± 15.2 %, at the intermediate stages — 80.9 ± 10.0 % and at the advanced stages — 72.2 ± 9.8 %. Long-term treatment results of young adults with intermediate and advanced stages of HL were inferior to those of adolescents. The frequency of secondary tumors in all patients was in 2.1 % of cases.