ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Immunomodulator Imunofan affects cell profile of morphofunctional zones of rat thymus and delays its age-related involution
About authors
Department of Histology, Cytology and Embryology, Faculty of Stomatology,Lugansk State Medical University, Lugansk, Ukraine
Correspondence should be addressed: Inessa Bobrysheva
ul. 15-ya Liniya, d.18, kv. 8, Lugansk, Ukraine, 91016; ur.liam@gul_asseni
Received: 2016-05-31
Accepted: 2016-06-22
Published online: 2017-01-05
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Fig. 1. Age-related involution of the thymus in random-bred albino male rats
Microphotographs of thymic sections obtained from pubertal male rats (A) and 20-month-old rats (B) one day after the administration of sodium chloride solution. 1 — the subcapsular zone of the cortex; 2 — the inner zone of the cortex; 3 — the medulla. Staining: hematoxylin-eosin. Objective lens: PlanC N х10/0,25 ∞/–/FN22. Zoom 132.
Fig. 2. Cell profile of the subcapsular zone of the thymic cortex of aging rats at various time points after injections of the immunomodulatory agent Imunofan
* — p <0.05 when comparing the experimental and the control groups.
Fig. 3. Cell profile of the inner zone of the thymic cortex in aging rats at various time points after injections of the immunomodulatory agent Imunofan
* — p <0.05 when comparing the experimental and the control groups.
Fig. 4. Cell profile of the thymic medulla in aging rats at various time points after injections of the immunomodulatory agent Imunofan
* — p <0.05 when comparing the experimental and the control groups.
