ORIGINAL RESEARCH

Trophic changes in the skeletal muscles of rats after therapy with sildenafil and cerebrolysin in the lower limb ischemia model

About authors

1 Research Laboratory “Genetics”,
Kursk State University, Kursk, Russia

2 Kursk State Medical University, Kursk, Russia

Correspondence should be addressed: Ekaterina Loyko
19 Stepnoy pereulok, d. 14, Kursk, Russia, 305025; ur.xednay@noom.nyrtak

About paper

Acknowledgements: authors thank professor Victor Lazarenko (Kursk State Medical University) and professor Alexandr Khudin (Kursk State University) for providing research facilities for the experiment.

Received: 2016-08-20 Accepted: 2016-08-27 Published online: 2017-01-05
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  1. Tkachuk VA, Bochkov VN, Philippova MP, Stambolsky DV, Kuzmenko ES, Sidorova MV, et al. Identification of an atypical lipoprotein-binding protein from human aortic smooth muscle as T-cadherin. FEBS Lett. 1998 Jan 16; 421 (3): 208–12. PubMed PMID: 9468307.
  2. Kirichenko AA, Novichkova N. Khronicheskaya ishemicheskaya bolezn’ nog. Moscow; 1998. 24 p. Russian.
  3. Pokrovsky MV, Kolesnik IM, Chodov SV, Intercession TG, Dolzhikov AA, Ephremenkova DA, et al., inventors; Kursk State Medical University, assignee. Sposob farmakologicheskoy korrektsii ishemii skeletnoy myshtsy sildenafilom, v tom chisle pri I-name-indutsirovannom defitsite oksida azota. Patent RU 2497203. 2013 Oct 27. Russian.
  4. Knyazev VV. Mikroskopicheskoe issledovanie reparativnoy regeneratsii nervnykh volokon posle khimicheskoy desimpatizatsii. In: Universitetskaya nauka: Vzglyad v budushchee. Sbornik trudov 72 nauchnoy konferentsii KGMU i sessii Tsentral'no-Chernozemnogo nauchnogo tsentra RAMN. Rossiyskiy simpozium «Zakonomernosti integratsii fiziologicheskikh funktsiy v norme i ikh dezintegratsiya v patologii»; 2007 Feb 1–2; Kursk, Russia. Vol. 1. Kursk: KGMU; 2007. p. 116–9. Russian.
  5. Kovalenko V, Kalitko I, Temrezov M, Chemurziev R, Petrov A. Vozmozhnosti lecheniya bol'nykh s aterotromboticheskim porazheniem arteriy nizhnikh konechnostey. Vrach. 2010; (3): 55–8. Russian.
  6. Sepiashvili RI, Shubich MG, Karpyuk VB. Oksid azota pri astme i razlichnykh formakh immunopatologii. Astma. 2009; 2 (2): 5–14. Russian.
  7. Chervyakov YuV, Staroverov IN, Nersisyan EG, Isaev AA, Deev RV. [Therapeutic angiogenesis in treatment of patients with chronic obliterating diseases of lower limb arteries]. Angiology and Vascular Surgery. 2012. 18 (3): 19–27. Russian.
  8. Rowe VL, Lee W, Weaver FA, Etzioni D. Patterns of treatment for peripheral arterial disease in the United States: 1996–2005. J Vasc Surg. 2009 Apr; 49 (4): 910–7.
  9. Gorchakov VD, Sergienko VI, Vladimirov VG. Selektivnye gemosorbenty. Moscow: Meditsina; 1989. 221 p. Russian.
  10. Pokrovskaja TG, Chuljukova TN, Pokrovskii TV [Endothelioprotective effects of sildenafil and tadalafil at experimental model of the I-name-induced deficiency of nitric oxide]. Kubanskii nauchnyi meditsinskii vestnik. 2009. 4: 136–9. Russian.
  11. Pokrovskaya TG, Chulyukova TN, Pokrovskiy MV, Filippenko NG. Endotelioprotektivnye dozozavisimye effekty sildenafila v kombinatsiyakh s L-argininom pri eksperimental'nom modelirovanii L-NAME-indutsirovannogo defitsita oksida azota. Biomedicine. 2010. 1 (5): 118–20. Russian.
  12. Masliah E, Díez-Tejedor E. The pharmacology of neurotrophic treatment with Cerebrolysin: brain protection and repair to counteract pathologies of acute and chronic neurological disorders. Drugs Today (Barc.). 2012. 48 Suppl A: 3–24.
  13. González ME, Francis L, Castellano O. Antioxidant systemic effect of short-term Cerebrolysin administration. J Neural Transm Suppl. 1998. 53: 333–41.
  14. Sugita Y, Kondo T, Kanazawa A, Itou T, Mizuno Y. [Protective effect of FPF 1070 (cerebrolysin) on delayed neuronal death in the gerbil-detection of hydroxyl radicals with salicylic acid]. No To Shinkei. 1993. 45 (4): 325–31. Japanese.
  15. EVER Neuro Pharma. Cerebrolysin — product monograph. 2010. 84 p.
  16. Gambaryan PP, Dukelskaya NM. Krysa. Moscow: Sovetskaya nauka; 1955. 254 p. Russian.
  17. Artyushkova EB, Pashkov DV, Pokrovsky MV, Faitelson AV, Gudyrev OS, Pokrovskaya TG, et al. [Possibilities of pharmacological correction of experimental chronic limb ischemia]. Éksperimentalnaya i Klinicheskaya Farmakologiya. 2008; 71 (3): 23–5. Russian.
  18. Young W, Keck WM. Tserebrolizin: obzor klinicheskikh i eksperimental'nykh issledovaniy. Prakticheskaya angiologiya [Internet]. 2009 [cited 2016 Sep 1]; 8 (27): [about 8 p.]. Available from: http://angiology.com.ua/ru-issue-article-273. Russian.
  19. Kolesnik IM, Lasarenko VA Pokrovskiy MV. [The influence of pharmacological preconditioning with sildenafil and vardenafil on condition of microvasculature in the ischemic skeletal muscle]. Kursk Scientific and Practical Bulletin "Man and His Health". 2015; (1): 83–6. Russian.
  20. Beyer S, Speich R, Fischler M, Maggiorini M, Ulrich S. Long-term experience with oral or inhaled vasodilator combination therapy in patients with pulmonary hypertension. Swiss Med Wkly. 2006 Feb 18; 136 (7–8): 114–8.
  21. Das S, Maulik N, Das DK, Kadowitz PJ, Bivalacqua TJ. Cardioprotection with sildenafil, a selective inhibitor of cyclic 3',5'-monophosphate-specific phosphodiesterase 5. Drugs Exp Clin Res. 2002; 28 (6): 213–9.
  22. Vertkin AL. Klinicheskaya farmakologiya ingibitorov FDE 5: vzglyad klinicheskogo farmakologa. Consilium medicum. 2004; 6 (7): 502–5. Russian.
  23. Alvarez XA, Lombardi VR, Fernández-Novoa L, Garciá M, Sampedro C, Cagiao A, et al. Cerebrolysin reduces microglial activation in vivo and in vitro: a potential mechanism of neuroprotection. J Neural Transm. Suppl. 2000; 59: 281–92.
  24. Lombardi VR, Windisch M, García M, Cacabelos R. Effects of Cerebrolysin on in vitro primary microglial and astrocyte rat cell cultures. Methods Find Exp Clin Pharmacol. 1999; 21 (5): 331–8.