2016 / 04

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DOI: 10.24075/brsmu.2016-04-05

ORIGINAL RESEARCH

Contrast enhanced MRI of tumors using gadopentetic acid linked to cyclodextrin by an ester bond

Kulakov VN1, Lipengolts AA1,2, Grigorieva EYu2, Semeikin AV3, Abakumov MA3, Karakhanov EA4, Maximov AB4, Shimanovsky NL3
About authors

1 Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia

2 N. N. Blokhin Russian Cancer Research Center, Moscow, Russia

3 P. V. Sergeev Molecular Pharmacology and Radiobiology Department, Biomedical Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia

4 Department of Petroleum Chemistry and Organic Catalysis, Faculty of Chemistry,
Lomonosov Moscow State University, Moscow, Russia

Correspondence should be addressed: Nikolay Shimanovsky
ul. Ostrovityanova, d. 1, Moscow, Russia, 117997; ur.umsr@namihs

About paper

Funding: this work was supported by Government Contract No. 11411.1008700.13.081 dated September 13, 2011 as part of the Federal Targeted Program for the Development of Pharmaceutical and Medical Industry of the Russian Federation until 2020.

Received: 2016-08-15 Accepted: 2016-08-25 Published online: 2017-01-05
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Fig. 1. MR images of mice with transplanted tumors (А — Са755, B — LLC and C — В16) before contrast administration
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Fig. 2. MR images of mouse breast adenocarcinoma Ca755 5 minutes after injecting (А) Magnevist and (B) K14-1. The tumor area is circled
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Fig. 3. MR images of mouse Lewis lung adenocarcinoma LLC 5 minutes after injecting (А) Magnevist and (B) K14-1. The tumor area is circled
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Fig. 4. MR images of mouse melanoma B16 5 minutes after injecting (А) Magnevist and (B) K14-1. The tumor area is circled
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Fig. 5. The curve shows dependency between signal-to-noise ratio in normal and tumor tissues and time elapsed after the injection of the studied contrast agents (A — Magnevist; B — K14-1) in mouse melanoma B16-F10
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Table 1. Т1-relaxivity and properties of the obtained samples
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Table 2. Comparison of Magnevist and β-CD derivative (sample К14-1) effect on rat fibroblast viability
Note. # — data are presented as percentage from the control; the control is taken as 100 %.
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