ORIGINAL RESEARCH

Analysis of mildronate effect on the catalytic activity of cytochrome Р450 3А4

About authors

1 Laboratory of Bioelectrochemistry, Department of Personalized Medicine,
Institute of Biomedical Chemistry, Moscow, Russia

2 Department of Biochemistry, Biomedical Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia

3 Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, Faculty of General Medicine,
I. M. Sechenov First Moscow State Medical University, Moscow, Russia

4 Institute of Bioorganic Chemistry of the National Academy of Sciences, Minsk, Republic of Belarus

Correspondence should be addressed: Victoria Shumyantseva
ul. Pogodinskaya, d. 10, Moscow, Russia, 119121; ur.liam@avestnaymuhs_v

About paper

Funding: this work was conducted under the Federal Fundamental Scientific Research Program for 2013–2020.

Received: 2016-11-28 Accepted: 2016-12-06 Published online: 2017-01-19
|
  1. Guengerich FP. Human Cytochrome P450 Enzymes. In: Ortiz de Montellano PR, editor. Cytochrome P450: Structure, Mechanism, and Biochemistry. San Francisco: Springer; 2015. p. 523–785.
  2. Hrycay EG, Bandiera SM. Involvement of Cytochrome P450 in Reactive Oxygen Species Formation and Cancer. Adv Pharmacol. 2015; 74: 35–84.
  3. Hrycay EG, Bandiera SM. The monooxygenase, peroxidase, and peroxygenase properties of cytochrome P450. Arch Biochem Biophys. 2012 Jun 15; 522 (2): 71–89.
  4. Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013 Apr; 138 (1): 103–41.
  5. Nebert DW, Russel DW. Clinical importance of the cytochromes P450. Lancet. 2002 Oct 12; 360 (9340): 1155–62.
  6. Zhou SF, Xue CC, Yu XQ, Li C, Wang G. Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring. Ther Drug Monit. 2007 Dec; 29 (6): 687–710.
  7. Hisaka A, Ohno Y, Yamamoto T, Suzuki H. Prediction of pharmacokinetic drug–drug interaction caused by changes in cytochrome P450 activity using in vivo information. Pharmacol Ther. 2010 Feb; 125 (2): 230–48.
  8. Zhang L, Reynolds KS, Zhao P, Huang SM. Drug interactions evaluation: an integrated part of risk assessment of therapeutics. Toxicol Appl Pharmacol. 2010 Mar; 243 (2): 134–45.
  9. Carrara S, Cavallini A, Erokhin V, De Micheli G. Multi-panel drugs detection in human serum for personalized therapy. Biosens Bioelectron. 2011 May 15; 26 (9): 3914–9.
  10. Schneider E, Clark DS. Cytochrome P450 (CYP) enzymes and the development of CYP biosensors. Biosens Bioelectron. 2013 Jan 15; 39 (1): 1–13.
  11. Rua F, Sadeghi SJ, Castrignanò S, Valetti F, Gilardi G. Electrochemistry of Canis familiaris cytochrome P450 2D15 with gold nanoparticles: An alternative to animal testing in drug discovery. Bioelectrochemistry. 2015 Oct; 105: 110–6.
  12. Panicco P, Dodhia VR, Fantuzzi A, Gilardi G. Enzyme-based amperometric platform to determine the polymorphic response in drug metabolism by cytochromes P450. Anal Chem. 2011 Mar 15; 83 (6): 2179–86.
  13. Shumyantseva VV, Bulko TV, Suprun EV, Chalenko YaM, Vagin MYu, Rudakov YuO, et al. Electrochemical investigations of cytochrome P450. Biochem Biophys Acta. 2011 Jan; 1814 (1): 94–101.
  14. Yarman A, Wollenberger U, Scheller FW. Sensors based on cytochrome P450 and CYP mimicking systems. Electrochim Acta. 2013; 110: 63–72.
  15. Fantuzzi A, Mak LH, Capria E, Dodhia V, Panicco P, Collins S, et al. A new standardized electrochemical array for drug metabolic profiling with human cytochromes P450. Anal Chem. 2011 May 15; 83 (10): 3831–9.
  16. The Protein Data Bank [база данных, Интернет]. Rutgers (NJ): the Research Collaboratory for Structural Bioinformatics; 2003– [про- цитировано 01.12.2016]. Доступно по: http://www.rcsb.org/
  17. PubChem [база данных, Интернет]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004– [процитировано 01.12.2016]. Доступно по: https://pubchem.ncbi.nlm.nih.gov/
  18. Shumyantseva VV, Makhova AA, Bulko TV, Kuzikov AV, Shich EV, Kukes VG, et al. Electrocatalytic cycle of P450 cytochromes: the protective and stimulating roles of antioxidants. RSC Adv. 2015; 5: 71306–13.
  19. Zadionchenko VS, Shekhyan GG, Yalymov AA, Asymbekova EU, Tugeeva EF, Sherstyannikova OM. Mesto mel'doniya v metabolicheskoi tsitoprotektsii. Russkii meditsinskii zhurnal. 2013; (9): 448–52. Russian.
  20. Mikhin VP, Pozdnyakov YuM, Khlebodarov FE, Koltsova ON. [Mildronate in cardiology practice — current evidence, ongoing research, and future perspectives]. Kardiovaskulyarnaya terapiya i profilaktika. 2012; 11 (1): 96–103. Russian.
  21. Statsenko ME, Turkina SV. Metabolicheskaya kardioprotektsiya
  22. Sadovnikova II. Kardioprotektory. Nedootsenennye vozmozhnosti.
  23. Samorodskaya IV. Mel'donii: obzor rezul'tatov issledovanii.
  24. Syrkin AL, Dobrovol'skii AV. Antiishemicheskie preparaty metabolicheskogo deistviya. Consilium Medicum. 2002; 4 (11):
  25. Shumyantseva VV, Makhova AA, Bulko TV, Bernhardt R,
  26. Omura T, Sato R. The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties. J Biol Chem. 1964 Jul; 239: 2379–85.
  27. Nash T. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochem J. 1953 Oct; 55 (3): 416–21.
  28. Sadeghi S, Ferrero S, Di Nardo G, Gilardi G. Drug–drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4. Bioelectrochemistry. 2012 Aug; 86: 87–91.
  29. Baj-Rossi C, Müller C, von Mandach U, De Micheli G, Carrara S. Faradic Peaks Enhanced by Carbon Nanotubes in Microsomal Cytochrome P450 Electrodes. Electroanalysis. 2015; 27: 1507– 15.
  30. Makhova AA, Shumyantseva VV, Shich EV, Bulko TV, Kukes VG, Sizova OS, et al. Electroanalysis of cytochrome P450 3A4 catalytic properties with nanostructured electrodes: The influence of vitamins B group on diclofenac metabolism. BioNanoSci. 2011; 1: 46–52.
  31. Shumyantseva VV, Makhova AA, Bulko TV, Shich EV, Kukes VG, Usanov SA, et al. The effect of antioxidants on electrocatalytic activity of cytochrome P450 3A4. Biochem (Mosc) Suppl Ser B Biomed Chem. 2013; 7: 160–4.
  32. Kimura Y, Ito H, Ohnishi R, Hatano T. Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity. Food Chem Toxicol. 2010 Jan; 48 (1): 429–35.