2023 / 04

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DOI: 10.24075/brsmu.2023.032

ORIGINAL RESEARCH

Clinical significance of cytokine counting in patients with multiple sclerosis and its relationship with herpes infection

Baranova NS1, Gris MS1, Baranov AA1, Spirin NN1, Artyuhov AS2, Shakirova KM2, Nasonov EL3,4
About authors

1 Yaroslavl State Medical University, Yaroslavl, Russia

2 Pirogov Russian National Research Medical University, Moscow, Russia

3 Nasonova Research Institute of Rheumatology, Moscow, Russia

4 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia

Correspondence should be addressed: Natalia S. Baranova
Revolutsionnaya, 5, Yaroslavl, 150000, Russia; ur.liam@sn_avonarab

About paper

Funding: the work was supported by the Innovations Assistance Fund within the framework of the UMNIK program: Participant of the youth scientific and innovative competition (contracts № 3560GU1/2014 of 23.09.2014, № 8815GU2/2015 of 17.12.2015).

Author contribution: NS Baranova, MC Gris — study planning and design, data analysis, manuscript authoring; MC Gris, AS Artyukhov, KM Shakirova — data collection and research; AA Baranov — data analysis; all autors — manuscript editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Yaroslavl State Medical University (Minutes № 1 of October 1, 2013). All patients signed a voluntary informed consent.

Received: 2023-07-24 Accepted: 2023-08-20 Published online: 2023-08-31
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Table 1. Clinical characteristics of the MS patients (Me (25th, 75th percentile), n = 36)
Table 2. Clinical characteristics of MS patients with and without clinical signs of PHVI reactivation (Me; 25th, 75th percentile)
Note: * — p < 0.05 between groups.
Table 3. Concentration (Me; 25th, 75th percentile) of cytokines in blood serum of participants from the MS and control groups
Note: * — p < 0.001 compared to the control group, ° — p < 0.01 compared to the MS group's no exacerbation subgroup.
Table 4. Concentration (Me; 25th, 75th percentile) of cytokines in blood serum of MS patients exhibiting clinical signs of reactivation of PHVI and not
Note: * — p < 0.05; * * — p < 0.01 between groups.