ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Changes in the sensitivity of human glioblastoma cells to oncolytic enteroviruses induced by passaging
About authors
1 Engelhardt Institute of Molecular Biology, Moscow
2 Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow
Correspondence should be addressed: Peter M. Chumakov
ul. Vavilova 32, Moscow, 119991; moc.oohay@mpvokamuhc
About paper
Funding: this work was supported by the Ministry of Education and Science of the Russian Federation (Project ID RFMEFI60714X0014).
Received: 2018-06-16
Accepted: 2018-07-22
Published online: 2018-07-08
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Fig. 1. Sensitivity of primary glioblastoma cell cultures obtained from 3 patients (A) and the same cells from passage 6 (B) to 4 strains of non-pathogenic oncolytic enteroviruses: —○— — type 1 poliovirus; --∆-- — Coxsackie virus А7; —□— — Echovirus 1; ···●··· — Echovirus 12. The horizontal scale (10-8–10-2) shows 10-fold dilutions of virus preparations
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Table 1. Infectious titers of viruses produced in primary and passaged glioblastoma cell cultures infected at a low multiplicity of infection (<0.001 infectious units per cell)
