DOI: 10.24075/brsmu.2018.063


Bioluminescent imaging: new opportunities

About authors

1 Biomolecular Chemistry Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow

2 Laboratory of Natural Compounds Chemistry, Pirogov Russian National Research Medical University, Moscow

Correspondence should be addressed: Alexander S. Shcheglov
Miklukho-Maklaya, 16/10, Moscow, 117997; ur.liam@trakuj

About paper

Funding: the study was funded by the Ministry of Science and Higher Education of the Russian Federation under the Federal Targeted Programme for Research and Development in Priority Areas of Development of the Russian Scientific and Technological Complex for 2014-2020, Agreement # 14.613.21.0062, project identifier RFMEFI61317X0062.

Received: 2018-11-02 Accepted: 2018-11-19 Published online: 04.12.2018

Modern biomedical research technologies actively use bioimaging for studying cells, tissues and whole organisms. Multicolor bioimaging is applied when simultaneous observation of different events at the molecular and cellular level is needed. Bioluminescent imaging methods are the most sensitive, however, their use for multicolor labeling is complicated due to the insufficient number of available uciferin-luciferase pairs. Having a number of advantages compared to previously studied bioluminescent systems, the new bioluminescence systems of higher fungi and marine polychaete Odontosyllis could become a useful expansion of the bioimaging toolbox.

Keywords: bioluminescence, bioimaging, luciferin, luciferase