ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
OPINION
Poly(3-hydroxyalkanoate)-based drug formulations: the micro- and nanostructure
About authors
1 Faculty of Biology, Lomonosov Moscow State University, Moscow
2 Bakh Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow
Correspondence should be addressed: Anton P. Bonartsev
Leninskie gory, 1 bl. 12, Moscow, 119234; ur.liam@ranob_tna
About paper
Funding: this work was supported by the grant of the Russian Science Foundation (project 17-74-20104, section 1) and the grant of the Russian Foundation for Basic Research (project 15-29-04856, section 2).
Received: 2018-08-26
Accepted: 2018-09-22
Published online: 2018-12-30
|
Fig. 1. PHB-derived microparticles with encapsulated DS: microparticles loaded with paclitaxel (A); microparticles loaded with doxorubicin (B); coumarin crystals on the surface of a microparticle loaded with this substance (C); microparticles loaded with methotrexate (D)
Fig. 2. А. A schematic representation of chain packing in single PHB crystals (Iwata T. et al. [9]). B. The rough (a) and smooth (b) surfaces of a macroscopic PHB film and the cross-section of a lamellar stack (marked with a green arrow) (c). C. A topographic image of an ultrathin PHB film; the crystalline structure of the polymer can
be clearly seen [19]
