2019 / 01

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DOI: 10.24075/brsmu.2019.011

ORIGINAL RESEARCH

A correlation between the fluctuations of cytokine concentrations measured in the morning and evening and the circadian blood pressure rhythm in patients with stage II essential hypertension

Radaeva OA1, Simbirtsev AS2, Khovryakov AV3
About authors

1 National Research Mordovia State University, Saransk, Russia

2 State Research Institute of Highly Pure Biopreparations, FMBA, St. Petersburg, Russia

3 Mordovian Republican Clinical Hospital No.4, Saransk, Russia

Correspondence should be addressed: Olga A. Radaeva
Ulianova 26/a, Saransk, 430030; ur.liam@97_fybwbltv

About paper

Author contribution: Radaeva OA recruited the study participants, collected blood samples, interpreted the results, analyzed the literature, and helped to write a draft of the manuscript. Simbirtsev AS supervised the research group, identified the aims and objectives of the study, proposed a methodology, and provided critical feedback. Khovryakov AV recruited the study participants, collected blood samples and wrote the manuscript.

Received: 2018-07-16 Accepted: 2019-03-01 Published online: 2019-03-13
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Table 1. Morning and evening concentrations of cytokines (pg/ml) in the serum samples of patients with stage II EH (duration of 10 to 14 years, no antihypertensive treatment applied)
Note: significance of differences: ' — < 0.05, ^ — < 0.01, * — < 0.001 (comparison with the specified group). The data are presented as an arithmetic mean (M) and a standard deviation (SD).
Table 2. The relationships between morning and evening concentrations of cytokines (pg/ml) in the serum samples of patients with stage II EH (duration of 10 to 14 years, no antihypertensive treatment applied) AND the blood pressure phenotype
Note: significance of differences: ' — < 0.05, ^ — < 0.01, * — < 0.001 (comparison with the specified group); 1 — 7:00 a.m., dippers, 2 — 8:00 p.m, dippers, 3 — 7:00 a.m., non-dippers, 4 — 8:00 p.m., non-dippers, 5 — 7:00 a.m., night-peakers, 6 — 8:00 p.m, night-peakers. The data are presented as a median (Ме) and an interquartile range [С25-С75].