2019 / 01

Next Paper
DOI: 10.24075/brsmu.2019.010

ORIGINAL RESEARCH

Injectable collagen in correction of age-related skin changes: experimental and clinical parallels

Manturova NE1, Stenko AG2, Petinati YaA3, Chaikovskaya EA2, Bolgarina AA4
About authors

1 Pirogov Russian National Research Medical University, Moscow, Russia

2 Institute of plastic surgery and cosmetology, Moscow, Russia

3 Izmerov Research Institute of Occupational Health, Moscow, Russia

4 LLC Nearmedic PLUS, Moscow, Russia

Correspondence should be addressed: Ekaterina A. Chaikovskaya
Olkhovskaya, 27, Moscow, 105066; ur.xednay@ayaksvokiahctk

About paper

Acknowledgements: the authors would like to thank “Nearmedic Plus” (Moscow) for the support of the clinical observational study, as well as Natalya Indilova, Galina Sofinskaya, Evgenia Ikonnikova, medical researchers of the Institute of Plastic Surgery and Cosmetology, and Olga Bondareva and Olesya Sidorova, doctors with Cosmoprodtest SPC, for the assistance they provided in the context of this study.

Author contribution: Manturova NE — research planning and data interpretation; Stenko AG, Petinati YaA — selection of participants, conducting research, data interpretation; Chaikovskaya EA — research planning, data collection and interpretation, manuscript preparation; Bolgarina AA — literature analysis, research planning.

Received: 2018-09-27 Accepted: 2019-02-25 Published online: 2019-03-10
|
  1. Rittié L, Fisher GJ. Natural and sun-induced aging of human skin. Cold Spring Harb Perspect Med. 2015; 5 (1): a015370.
  2. Gunn DA, Rexbye H, Griffiths CE, Murray PG, Fereday A, Catt SD, et al. Why Some Women Look Young for Their Age. Tregenza T, ed. PLoS ONE. 2009; 4 (12): e8021.
  3. Nkengne A, Bertin C, Stamatas GN, Giron A, Rossi A, Issachar N, et al. Influence of facial skin attributes on the perceived age of Caucasian women. J Eur Acad Dermatol Venereol. 2008: 22 (8): 982–91.
  4. Hussain SH, Limthongkul B, Humphreys TR. The biomechanical properties of the skin. Dermatol Surg. 2013; 39 (2): 193–203.
  5. Aziz J, Shezali H, Radzi Z, Yahya NA, Abu Kassim NH, Czernuszka J, et al. Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin. Skin Pharmacol Physiol. 2016; 29 (4): 190–203.
  6. Czekalla C, Schönborn KH, Döge N, Jung S, Darvin ME, Lademann J, et al. Impact of Body Site, Age, and Gender on the Collagen/Elastin Index by Noninvasive in vivo Vertical Two-Photon Microscopy. Skin Pharmacol Physiol. 2017; 30 (5): 260–7.
  7. Baroni Edo R, Biondo-Simões Mde L, Auersvald A, Auersvald LA, Montemor Netto MR, Ortolan MC, et al. Influence of aging on the quality of the skin of white women: the role of collagen. Acta Cir Bras. 2012; 27 (10): 736–40.
  8. Kapuler O, Selskaja B, Galeeva A, Kamilov F. Metabolizm kollagenovyh volokon na fone vozrastnyh izmenenij. Vrach. 2015; (8): 64–9.
  9. Quan T, Fisher GJ. Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review. Gerontology. 2015; 61 (5): 427–34.
  10. Calleja-Agius J, Brincat M, Borg M. Skin connective tissue and ageing. Best Pract Res Clin Obstet Gynaecol. 2013; 27 (5): 727–40.
  11. Danby FW. Nutrition and aging skin: sugar and glycation. Clin Dermatol. 2010; 28 (4): 409–11.
  12. Ahmed T, Nash A, Clark KE, Ghibaudo M, de Leeuw NH, Potter A, et al. Combining nano-physical and computational investigations to understand the nature of "aging" in dermal collagen. Int J Nanomedicine. 2017; (12): 3303–14.
  13. Moragas A, Garcia-Bonafé M, Sans M, Torán N, Huguet P, Martin-Plata C. Image analysis of dermal collagen changes during skin aging. Analyt Quant Cytol Histol. 1998; (20): 493–9.
  14. El-Domyati M, Attia S, Saleh F, Brown D, Birk DE, Gasparro F, et al. Intrinsic aging VS photoaging: a comparative histopathological, immunohistochemical and ultrastructural study of skin. Exp Dermatol. 2002; (11): 398–405.
  15. Yaar M, Eller MS, Gilchrest BA. Fifty years of skin aging. J Invest Dermatol. 2002; (7): 51–8.
  16. Cheng W, Yan-hua R, Fang-gang N, Guo-an Z. The content and ratio of type I and III collagen in skin differ with age and injury. African J Biotechnol. 2011; 10 (13): 2524–9.
  17. Fisher GJ, Varani J, Voorhees JJ. Looking older: fibroblast collapse and therapeutic implications. Arch Dermatol. 2008; 144 (5): 666–72.
  18. Cole MA, Quan T, Voorhees JJ, Fisher GJ. Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging. J Cell Commun Signal. 2018; 12 (1): 35–43.
  19. Varani J, Spearman D, Perone P, Fligiel SE, Datta SC, Wang ZQ, et al. Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro. Am J Pathol. 2001; 158 (3): 931–42.
  20. Sawamura S, Jinnin M, Kajihara I, Makino K, Aoi J, Ichihara A, et al. Do scleroderma patients look young? Evaluation by using facial imaging system. Drug Discov Ther. 2017; 11 (6): 342–5.
  21. Kamilov FH, Selskaja BN, Danilova OV, Kapuler OM. Metabolizm kollagena v kozhe jeksperimental'nyh zhivotnyh pri intradermal'noj in’ekcii nemodificirovannogo bych'ego kollagena tipa I. Vestnik Udmurdskogo universiteta. 2017; 27 (3): 356–61.
  22. Kruglikov I. Neocollagenesis in Non-Invasive Aesthetic Treatments. J Cosmet Dermatol Sci Appl. 2013; 3 (1A): 1–5.
  23. Shao Y, He T, Fisher GJ, Voorhees JJ, Quan T. Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo. Int J Cosmet Sci. 2017; 39 (1): 56–65.
  24. Wang F, Garza LA, Kang S, Varani J, Orringer JS, Fisher GJ, et al. In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin. Arch Dermatol. 2007; 143 (2): 155–63.
  25. Yutskovskaya Y, Kogan E, Leshunov E. A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-based dermal filler. J Drugs Dermatol. 2014; 13 (9): 1047–52.
  26. Stein P, Vitavska O, Kind P, Hoppe W, Wieczorek H, Schürer NY. The biological basis for poly-L-lactic acid-induced augmentation. J Dermatol Sci. 2015; 78 (1): 26–33.
  27. Rao KP. Recent developments of collagen-based materials for medical applications and drug delivery systems. J Biomater Sci Polymer Ed. 1995; 7 (7): 623–45.
  28. Katayama K, Armendariz-Borunda J, Raghow R, Kang AH, Seyer JM. A pentapeptide from type I procollagen promotes extracellular matrix production. J Biol Chem. 1993; 268 (14): 9941–4.
  29. Maquart FX, Pasco S, Ramont L, Hornebeck W, Monboisse JC. An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity. Implication in tumor invasion. Crit Rev Oncol Hematol. 2004; 49 (3): 199–202.
  30. Abojanc RK, Istranov LP, Istranova EV, Rudenko TG. Plasticheskie materialy napravlennogo dejstvija na osnove kollagena. Jelektronnyj sbornik nauchnyh trudov "Zdorov'e i obrazovanie v XXI veke". 2011; (4): 184.
  31. Kubanova AA, Smoljannikova VA, Sluzhaeva NG. Starenie kozhi i vozmozhnosti korrekcii preparatom kollagena. Vestnik dermatologii i venerologii. 2007; (5): 70–3.
  32. Kapuler OM, Kuramshina ER. Prikladnye aspekty kollagenoterapii v jesteticheskoj medicine. Jeksperimental'naja i klinicheskaja dermatokosmetologija. 2013; (5): 40–3.
  33. Gejnic AV, Kiani A, Okushko SS. Novye vozmozhnosti primenenija glubokoj i poverhnostnoj frakcionnoj abljacii v anti-age terapii. Plasticheskaja hirurgija i kosmetologija. 2013; (4): 625–32.
  34. Alexiades-Armenakas M, Newman J, Willey A, Kilmer S, Goldberg D, Garden J, et al. Prospective multicenter clinical trial of a minimally invasive temperature-controlled bipolar fractional radiofrequency system for rhytid and laxity treatment. Dermatol Surg. 2013; 39 (2): 263–73.
  35. Carruthers A, Carruthers J. A validated facial grading scale: the future of facial ageing measurement tools? J Cosmet Laser Ther. 2010; 12 (5): 235–41.
  36. Tsukahara K, Tamatsu Y, Sugawara Y, Shimada K. The relationship between wrinkle depth and dermal thickness in the forehead and lateral canthal region. Arch Dermatol. 2011; 147 (7): 822–8.
  37. Waller JM, Maibach HI. Age and skin structure and function, a quantitative approach (I): blood flow, pH, thickness, and ultrasound echogenicity. Skin Res Technol. 2005; (11): 221–35.
  38. Jasaitiene D, Valiukeviciene S, Linkeviciute G, et al. Principles of high-frequency ultrasonography for investigation of skin pathology. J Eur Acad Dermatol Venereol. 2011; (25): 375–82.
  39. Kozarova A, Kozar M, Minarikova E, Pappova T. Identification of the age related skin changes using high-frequency ultrasound. Acta Medica Martiniana. 2017; 17 (1): 15–20.
  40. Lacarrubba F, Tedeschi A, Nardone B, Micali G. Mesotherapy for skin rejuvenation: assessment of the subepidermal low-echogenic band by ultrasound evaluation with cross-sectional B-mode scanning. Dermatol Ther. 2008; 21 (Suppl 3): 1–5.