ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Investigating a correlation between the levels of peripheral blood cytokines and the risk for cardiovascular complications in patients with stage II essential hypertension
About authors
1 National Research Mordovia State University, Saransk, Russia
2 State Research Institute of Highly Pure Biopreparations, FMBA, St. Petersburg, Russia
Correspondence should be addressed: Olga A. Radaeva
Ulianova 26/a, Saransk, 430030; ur.liam@97_fybwbltv
About paper
Author contribution: Radaeva OA recruited patients, collected blood samples for the study took medical histories, interpreted the study results, and wrote the manuscript. Simbirtsev AS conceived and planned the study, analyzed the obtained data and revised the manuscript.
Received: 2018-07-16
Accepted: 2019-02-27
Published online: 2019-03-07
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Table 1. Cytokine levels in patients in treatment for stage II EH who developed cardiovascular complications during the 5-year follow-up period and those who did not
have any complications. М (σ)
Note: ^ — p < 0.01; * — p < 0.001 in comparison with patients without complications reported in the 5-year follow-up period.
Table 2. The relationship between changes in IL1ra, IL1β, IL6, TNFα, M-CSF, and IL10 concentrations measured at the beginning of the study AND the rate of
complications (95% CI) during the 5-year follow-up period in patients in treatment for long-settled EH
Note: * — р < 0.05 for the comparison of absolute risks if the interval does not include 1.
Table 3. Correlations between IL1β, IL1ra, IL6, IL10, and M-CSF concentrations AND the rate of cardiovascular complications (95% CI) during the 5-year observation
period in patients with stage II EH. The univariate Cox regression
Note: in our Cox regression models, Beta is a regression coefficient; Standard is a standard error of the regression coefficient; t-value is the t-statistic; Exponent Beta is the value of the relative risk indicating a connection with the range of changes in the analyzed factor; p shows statistical significance.
Table 4. A correlation matrix for the cytokines in the peripheral blood of patients in treatment for stage II EH and the vasoactive peptides measured in the same patients
Note: the data are presented as a coefficient of multiple correlation; the minus symbol indicates that the established correlation is negative; р shows the significance of differences.
Table 5. A correlation matrix for the cytokines in the peripheral blood of patients in treatment for stage II EH and the vasoactive peptides measured in the same patients
Note: the data are presented as a coefficient of multiple correlation; the minus symbol indicates that the established correlation is negative; р shows the significance of differences.
Table 6. Correlations between IL1β, IL1ra, IL6, IL10, M-CSF, ADMA concentrations and classic risk factors AND the rate of cardiovascular complications (95% CI) in a
5-year observation period in patients with stage II EH; the table shows the Cox regression model; the multivariate analysis was applied
Note: in our Cox regression models, Beta is a regression coefficient; Standard is a standard error of the regression coefficient; t-value is the t-statistic; Exponent Beta is the value of the relative risk indicating a connection with the range of changes in the analyzed factor; p shows statistical significance.
