2019 / 02

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DOI: 10.24075/brsmu.2019.028

OPINION

Adenosine-to-inosine RNA editing may be implicated in human pathogenesis

Kliuchnikova AA1, Moshkovskii SA2
About authors

1 Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

2 Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Anna A. Kliuchnikova
Pogodinskaya 10, bld. 8, Moscow, 119121; moc.liamg@avokinhcuilk.a

About paper

Funding: the work was performed within The Programme for fundamental scientific research of state science academies for 2013–2020.

Author contribution: both authors have contributed equally to manuscript writing.

Received: 2018-08-13 Accepted: 2019-04-06 Published online: 2019-04-17
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Fig. 1. ADAR effects associated with human diseases. Changes in ADAR1 activities are assiciated with immune protection against viral infections and inflammation and with certain types of cancer; RNA editing in glutamate receptors normally occurs in CNS. ADAR2 effects are associated with both positive and negative impacts on tumor progression while its deficiency may cause various CNS disorders