2019 / 02

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DOI: 10.24075/brsmu.2019.026

ORIGINAL RESEARCH

A prognostic model for the prediction of generalized chronic periodontitis in patients with metabolic syndrome

Petrukhina NB1,2, Zorina OA2, Shikh EV, Kartysheva EV, Kudryavtsev AV2
About authors

1 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia

2 Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia

Correspondence should be addressed: Ekaterina V. Kartysheva
Bolshaya Pirogovskaya 2, bl. 4, Moscow, 119991; ur.liam@46467675098

About paper

Author contribution: Petrukhina NB and Shikh EV conceived the study, analyzed and interpreted the obtained data; Zorina OA analyzed and interpreted the obtained data; Kartysheva EV collected the samples, analyzed the literature and interpreted the obtained data; Kudryavtsev AV prepared the manuscript draft and analyze the literature.

Received: 2018-09-24 Accepted: 2019-03-31 Published online: 2019-04-14
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Fig. 1. The graph shoes the relationship between the risk of developing severe GCP and the TNF-α concentrations in the PP
Fig. 2. The ROC-curve represents a relationship between the diagnostic sensitivity and specificity in predicting the risk of severe GCP from the cytokine profile of the oral cavity
Fig. 3. A spreadsheet in Microsoft Exсel 2010 used for automatic calculations of the risk for severe GCP based on the oral cavity cytokine profile
Fig. 4. Integration of proinflammatory and osteotropic factors in bone resorption
Table 1. Levels of the key proinflammatory cytokine TNF-α in the PP exudate in patients with GCP and comorbid metabolic syndrome
Note: * — shows that the difference is significant.
Table 2. Sensitivity and specificity of the method at different values of the prognostic coefficient W used to predict the risk of severe GCP from the cytokine profile of the oral cavity
Note: * — marks the cut-off point.