2019 / 05

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DOI: 10.24075/brsmu.2019.059

ORIGINAL RESEARCH

The state of cognitive functions after angioreconstructive operations on the carotid arteries

Tanashyan MM, Medvedev RB, Lagoda OV, Berdnikovich ES, Skrylev SI, Gemdzhian EG, Krotenkova MV
About authors

Research Center of Neurology, Moscow, Russia

Correspondence should be addressed: Roman B. Medvedev
Volokolamskoye shosse 80, Moscow, 125367; ur.xednay@namor-vedevdem

About paper

Funding: the study was ordered by the Research Center of Neurology (Federal Research Institution).

Author contribution: Tanashyan MM — study design development, manuscript editing; Medvedev RB — literature analysis, study design development, data collection, analysis and interpretation, manuscript authoring; Lagoda OV and Berdnikovich ES — literature analysis, study design development, data collection and interpretation, manuscript editing; Skrylev SI — angiosurgery, manuscript editing; Gemdzhian EG — study concept and design, data analysis, statistical analysis, manuscript compilation and editing; Krotenkova MV — image data analysis and interpretation, manuscript editing.

Received: 2019-08-15 Accepted: 2019-08-29 Published online: 2019-09-17
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Fig. 1. Dynamics of the proportion of patients (Y axis, %) with different MMSE scores: no cognitive impairment (28–30 score) — upper fields, mild impairment (25–27 score) — middle fields, severe impairment (< 25 score) — two lower fields
Fig. 2. Dynamics of MMSE scores describing cognitive functions (pre- and post-surgery at different time points); mean values (with minimum and maximum) are presented
Fig. 3. Operative memory scores (10-word test) compared, pre-surgery (initial) and post-surgery (by the end of the observation period); N — norm (10 words); Md — mild impairments (8–9); Mt — moderate (6–7); S — severe (< 6). By the end of the observation period (9 months) all patients generally exhibited improvements of their operative memory
Fig. 4. CEP dynamics in patients with intraoperative acute ischemia foci (AIF+) and in patients without intraoperative acute ischemia foci (AIF–): during the observation period, the CEP level in the AIF+ group (n = 30) did not change, but in the AIF– group (n = 60) it decreased by 15% (p = 0.05). Normalized (divided by the initial levels) main CEP values (%) are given
Fig. 5. Possible changes in the brain matter and post-surgery cognitive functions deterioration vector
Table. Patient CF assessment scores (based on screening tests)*
Note: * — test results are presented as mean values with standard errors of mean (test result histograms are close to normal distribution).