ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Hepatoprotective effect of polyphenols in rats with experimental thioacetamide-induced toxic liver pathology
About authors
1 Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology” RAS, Moscow, Russia
2 Mendeleyev University of Chemical Technology of Russia, Moscow
3 Vavilov Institute of General Genetics, Moscow, Russia
Correspondence should be addressed: Maria S. Smirnova
Moskvina, 10–226, Khimki, Moscow Region, 141401; ur.ay@oktobrabm
About paper
Funding: the study was supported by the Ministry of Education and Science of the Russian Federation (agreement № 14.616.21.0083, unique project ID: RFMEFI61617X0083).
Acknowledgement: we thank to the Center for Precision Genome Editing and Genetic Technologies for Biomedicine (Moscow) for the genetic research methods.
Author contribution: Dergachova DI — conducting experiments on toxic hepatitis induction, histological analysis, manuscript draft preparation; Klein OI — histological studies, data acquisition and analysis; Marinichev AA — experiments on toxic hepatitis induction, blood sample collection from experimental animals, preparation of histological samples; Gessler NN — conducting experiments on toxic hepatitis induction, blood sample collection from experimental animals, data acquisition and analysis; Bogdanova ES, Smirnova MS — literature analysis, data acquisition and analysis; Isakova EP — conducting experiments on toxic hepatitis induction, literature analysis; Deryabina YI — experiment planning, literature analysis, data acquisition and analysis.
Received: 2019-10-26
Accepted: 2019-11-17
Published online: 2019-11-28
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Fig. 1. Dynamics of animals’ weight changes during the experiment: 1 — intact animals group; 2 — control group treated with TAA; 3–5 — groups of animals treated
with TAA together with polyphenols (RSV, DHM and PS respectively)
Fig. 2. AST (А) and ALT (B) change in the blood serum of rats during the experiment. * — p < 0.05 in relation to corresponding indicators of intact animals group; * * — p < 0.05 in relation to corresponding indicators of control group
Fig. 3. Micrographs of treatment groups animals’ liver sections stained with hematoxylin-eosin. А. Intact animals group (1). B, C. Control group (2). D. Treatment group (3). E. Treatment group (4). F. Treatment group (5). Magnification ×400
Table. Bilirubin level change in the blood serum of rats during the experiment
Note: * — p < 0.05 in relation to corresponding indicators of intact animals group; * * — p < 0.05 in relation to corresponding indicators of control group.
