ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Spread of variants with gene N hot spot mutations in russian SARS-CoV-2 isolates
About authors
DNA-Technology LLC, Moscow, Russia
Correspondence should be addressed: Sergei A. Kiryanov
PO Box 181, Moscow, 117587; ur.ygolonhcet-and@vonayrik
About paper
Author contribution: the authors contributed to the manuscript equally.
Received: 2020-06-26
Accepted: 2020-07-10
Published online: 2020-07-28
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Fig. 1. Phylogenetic analysis of Russian, European, and American SARS-CoV-2 sequences, distinguished by the double mutation R203K and G204R in gene N.
Russian isolates are highlighted in blue, European isolates in green and dark green, and American isolates in dark red
Fig. 2. Abundance of SARS-CoV-2 isolates carrying mutations R203K and G204R in gene N (Russia, March–April 2020)
Table 1. Subclusters and characteristic mutations identified in the SARS-CoV-2 isolates from Russia
Note: * mutations in the ORF1ab gene defining the subgroup of the isolate; ** mutations in other genes defining the subgroup of the isolate; *** other frequent mutations identified in the isolates.
Table 2. SARS-CoV2 B-cell epitope variants predicted in the nucleocapsid N protein
