ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Footprints of interaction among Finniс-speaking, Slavic, and Turkic-speaking populations in modern gene pool and their reflection in pharmacogenetics
About authors
1 Bochkov Research Centre of Medical Genetics, Moscow, Russia
2 Vavilov Institute of General Genetics, Moscow, Russia
3 Biobank of North Eurasia, Moscow, Russia
4 Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow, Russia
Correspondence should be addressed: Elena V. Balanovska
Moskvorechie, 1, 115522, Moscow, Russia; ur.liam@aksvonalab
About paper
Funding: the study was supported by RFBR grant 20-29-01017 Ancient DNA (bioinformatics analysis), RSF grant 21-14-00363 (analysis of pharmacogenetics markers), and State Assignment of the Ministry of Science and Higher Education of the Russian Federation to Vavilov Institute of General Genetics (cartographic analysis) and Bochkov Research Centre of Medical Genetics (data interpretation).
Acknowledgements: the authors thank all sample donors who participated in this study and the Biobank of North Eurasia for the access to DNA collections.
Received: 2022-04-01
Accepted: 2022-04-16
Published online: 2022-04-26
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Fig. 1. Contributions of the ancestral components identified by ADMIXTURE at k = 3, k = 7, and k = 8 to individual genomes in the studied populations. Each ancestral component is indicated by specific color; each vertical line represents individual genome with a palette of ancestral component contributions; the populations are demarcated by white lines; the raw data are given in the table
Fig. 2. Geographic ranges of three ancestral components identified by ADMIXTURE at k = 3: “Western” (A), “Ural” (B), and “Eastern” (C). High prevalence rates are colored red-to-purple, low values are green, the scale of transitions is given in the map; studied populations are indicated by red circles
Fig. 3. Geographic ranges of three ancestral components identified by ADMIXTURE at k = 7: “Slavic” (A), “Mordovian-1” (B), and “Mordovian-2” (C). High prevalence rates are colored red-to-purple, low values are green, the scale of transitions is given in the map; studied populations are indicated by red circles
Fig. 4. Fractions of individual genomes (%) harboring “Mordovian-1” and “Mordovian-2” ancestral components in ethnic Russian populations
Fig. 5. Pharmacogenetic landscape of the studied geographic area, representing genetic distances from Ryazan Russians according to pharmacogenetic markers. Small genetic distances (indicating pharmacogenetic proximity to Ryazan Russians) are shown in green; large genetic distances (indicating pharmacogenetic divergence from Ryazan Russians) are shown in red-to-purple; the scale of transitions is given in the map
Table. Estimated contribution of each of the ten ancestral components identified by ADMIXTURE at k = 3 and k = 7 to genomes in each of the studied populations
