ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Association of polymorphic variants of ACE and BDKRB2 with heart rate variability in athletes of the Republic of Karelia
About authors
1 Laboratory of Genetics, Institute of Biology,KarRC RAS, Petrozavodsk, Russia
2 Department of Human and Animal Physiology, Pathophysiology and Histology, Medical Institute,Petrozavodsk State University, Petrozavodsk, Russia
3 Research Group for Math-Modeling of Biomedical Systems,Research Institute for Molecular Biology and Biophysics, Novosibirsk, Russia
Correspondence should be addressed: Sergey Kolomeichuk
ul. Nevskogo, d. 50, Petrozavodsk, Russia, 185910; ur.relbmar@kuhcyemolok_yegres
About paper
Funding: this work was supported by the Russian Foundation for Assistance to Small Innovative Enterprises (the Umnik program) and the state-funded Project No. 0221-2014-0034.
Acknowledgements: the authors thank Olga Fedorenko, CSc, of the Institute of Biology, KarRC RAS, for her valuable comments.
Contribution of the authors to this work: Kolomeichuk SN — analysis of literature, research planning, data collection, analysis, and interpretation, drafting of a manuscript; Alekseev RV — selection of athletes, participation in collection of data about heart rate variability, statistical processing and discussion, research planning, data analysis and interpretation, drafting of a manuscript; Putilov AA — data analysis and interpretation, drafting of a manuscript; Meigal AYu — research planning, participation in collection of data about heart rate variability, statistical processing and discussion.
Received: 2017-08-25
Accepted: 2017-10-29
Published online: 2017-10-30
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Fig. 1. Frequency distribution of ACE allelic variants in the athletes from the Republic of Karelia specializing in different sports
Fig. 2. Frequency distribution of BDKRB2 allelic variants in the athletes from the Republic of Karelia specializing in different sports
Table 1. Results of the bioelectrical impedance analysis of body composition conducted in the study participants
Note. * — represents statistically significant differences (p<0.05) relative to the Strength group.
Table 2. Time domain parameters of heart rate variability
Note. R — R min and R — R max are minimal and maximal R-R (beat-to-beat) intervals; RRNN is mean normal-to-normal R-R interval; SDNN is standard deviation of normal-to-normal R-R intervals; RMSSD is root-mean square differences of successive NN intervals; pNN50, % is percentage of successive NN intervals with a >50 ms difference; CV is a variation coefficient. * represents statistically significant differences relative to the Strength group (tcrit. = 2.008; p < 0.05). Differences in time domain parameters of heart rate variability between the groups were estimated using the nonparametric Mann–Whitney U-test.
Table 3. Spectral parameters of heart rate variability of the participants
Note. TP is total power of the spectrum; VLF is very low frequency oscillations; LF is low frequency oscillations; HF is high frequency oscillations; LF norm and HF norm are normalized low and high frequency oscillations, respectively.
Table 4. Time-domain parameters of heart rate variability in athletes with different ACE genotypes
Note. * — represents significant difference relative to ACE I/I carriers (p < 0.05).
Table 5. Spectral parameters of heart rate variability in athletes with different ACE genotypes
Note. * — represents statistically significant differences relative to the ACE I/I group (p < 0.05).
Table 6. Time-domain parameters of heart rate variability in the athletes with different BDKRB2 genotypes
Note. * — represents statistically significant differences (p < 0.05) between the BDKRB2 –9/–9 and BDKRB2 +9/+9 groups.
Table 7. Spectral parameters of heart rate variability in athletes with different BDKRB2 genotypes
Note. * — represents statistically significant difference relative to the BDKRB2 –9/–9 group (p < 0.05).
