ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Polymorphism of the dtxR gene in the currently existing strains of Сorynebacterium diphtheriae
About authors
1 G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia
2 Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Andrey Viktorovich Chaplin
ul. Ostrovityanova, d. 1, Moscow, Russia, 117997; moc.liamg@kidemoloko
About paper
Funding: this study was conducted as part of two projects: The Study of the Role of Microbial Communities in Human Oropharynx and Blood in Diphtheria, Pertussis and Other Infectious Inflammatory Diseases (Project ID А16-116021550311-2) and The Development of Molecular-Genetic Methods for Laboratory Diagnosis of Diphtheria and Pertussis (Project ID АААА-А16-116101810127-7) supported by the Sectoral Research Program of the Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Problem-oriented Research in Epidemiological Surveillance of Infectious and Parasitic Diseases in 2016-2020).
Contribution of the authors to this work:Chagina IA — analysis of literature, data collection and interpretation, drafting of a manuscript; Perevarova YuS, Perevarov VV — analysis of literature, data analysis and interpretation, drafting of a manuscript; Chaplin AV — research planning, data analysis and interpretation, drafting of a manuscript; Borisova OYu — research planning, data collection and interpretation, drafting of a manuscript; Kafarskaya LI — data interpretation, drafting of a manuscript; Afanas’ev SS, Aleshkin VA — research planning, drafting of a manuscript. All authors participated in editing of the manuscript.
Received: 2017-02-02
Accepted: 2017-02-18
Published online: 2017-03-11
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The phylogenetic tree of С. diphtheriae strains based on the dtxR gene sequences
The tree is scaled to 0.1 substitutions per 200 b. p; branch lengths correspond to the evolutionary distances used to construct the tree. Sequences within groups are identical.
Table 1. Frequency of nucleotide substitutions in the dtxR gene of the studied strains of C. diphtheriae relative to the strain PW8
Table 2. Combinations of polymorphisms of the dtxR gene in C. diphtheriae strains
Note. * — a match with the reference; T, А — polymorphism with amino acid substitution.
Table 3. Group composition according to polymorphism combinations in the dtxR gene of C. diphtheriae strains
Note. * — MLST non performed, – — ST not found in the database.
