2019 / 04

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DOI: 10.24075/brsmu.2019.057

ORIGINAL RESEARCH

Contrast-enhanced ultrasonography for assessing neovascularization of carotid atherosclerotic plaque

Evdokimenko AN, Chechetkin AO, Druina LD, Tanashyan MM
About authors

Research Center of Neurology, Moscow, Russia

Correspondence should be addressed: Anna N. Evdokimenko
Volokolamskoe shosse 80, Moscow, 125367; ur.ygoloruen@oknemikodve

About paper

Funding: this study was supported by Research Center of Neurology Government funding.

Acknowledgment: the authors thank Skrylev SI, Shchipakin VL and Koshcheev AYu (Vascular and Endovascular Surgery Unit, Research Center of Neurology) for providing biopsy specimens.

Author contribution: Evdokimenko AN — literature analysis, study design, data acquisition and interpretation, manuscript preparation; Chechetkin AO — literature analysis, study design, data acquisition and interpretation, manuscript revision; Druina LD — data acquisition; Tanashyan MM — study design, manuscript revision.

Received: 2019-08-15 Accepted: 2019-08-30 Published online: 2019-08-31
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Fig. Quantitative methods for the assessment of carotid atherosclerotic plaque neovascularization from contrast-enhanced ultrasonography data. A. A heterogeneous, predominantly hypoechoic atherosclerotic plaque on a conventional Color Doppler Image. B. Contrast-enhanced ultrasonography: a predominantly hypoechoic atherosclerotic plaque with single hyperechoic echogenic components (blood vessels, shown by arrows), hyperechoic arterial lumen and surrounding tissue. C–E. Quantitative analysis of intraplaque neovascularization on a still frame showing the max number of blood vessels (the contour of the plaque is shown in red): ultrasound signal intensity (ROI) (C); the ratio of the total vessel area to the plaque area (blood vessels are shown in green) (D); blood vessel number per 1 cm2 of the plaque (blood vessels are shown in different colors) (E)
Table 1. Neovascularization of carotid plaques of different types (classification by Gray-Weale)
Table 2. Results of the semiquantitative analysis of contrast-enhanced ultrasonography data compared to the vessel density determined during the histopathologic examination (* — р ≤ 0.03)
Table 3. The correlation analysis of data on plaque neovascularization obtained from contrast-enhanced ultrasonography and the histopathologic examination (n = 65)
Table 4. The correlation analysis of data on neovascularization in different types of plaques obtained from contrast-enhanced ultrasonography and the histopathologic examination (classification by Gray-Weale)