ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
METHOD
Dynamic contrast-enhanced MRI in determining histological type of cervical cancer
About authors
1 Department of Roentgenology and Radiology,
Russian Medical Academy of Postgraduate Education, Moscow, Russia
2 N. N. Blokhin Russian Cancer Research Center, Moscow, Russia
3 P. V. Sergeev Molecular Pharmacology and Radiobiology Department, Biomedical Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Elena Tarachkova
ul. Barrikadnaya, d. 2/1, str. 1, Moscow, Russia, 123995; ur.xednay@dikrotcod
Received: 2016-08-10
Accepted: 2016-08-18
Published online: 2017-01-05
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Fig. 1. Magnetic resonance contrast agent accumulation curves obtained on the scanner workstation
An axial section is on the left, obtained from a dynamic contrast-enhanced MR image (80 s after scanning was launched) of a patient with squamous cell carcinoma. Regions of interest (ROIs) are shown in different colors. The yellow (1) and red (2) circles show cervical cancer, the green (3) circle shows intact myometrium, the blue circle (4) shows a blood vessel. Signal intensity-time curves based on the ROI data are shown on the right. The vertical line designates time elapsed after measurements were started (80 s). The horizontal axis shows time elapsed after contrast agent delivery to the tumor (seconds); the vertical axis shows relative signal intensity. A higher signal intensity is characteristic of intact myometrium and the vessel.
Fig. 2. A typical gadobutrol accumulation curve for two types of cervical cancer (squamous cell carcinoma and adenocarcinoma)
The horizontal axis shows time elapsed after contrast agent delivery to the tumor (seconds); the vertical axis shows relative signal intensity in tumor tissue (the red curve shows adenocarcinoma dynamics, the blue curve shows squamous cell carcinoma dynamics).
Table 1. Distribution of patients with cervical cancer into groups according to tumor histologic type and grade
Note. Lesion volume was measured directly (the sum of tumor square areas on T2-weighted images multiplied by section thickness). Grading was performed in 67 patients.
Table 3. Median values and the range of differences between studied parameters on fat-suppressed T2-weighted images and T1-weighted images after gadobutrol injection to the region of interest (no smaller than 15 pixels) for cervical cancer of two histologic types (squamous cell carcinoma and adenocarcinoma)
Note. SI is signal intensity; RSI(t) is relative signal intensity on T1-weighted images obtained during dynamic contrast-enhanced MRI at time point t (seconds) after gadobutrol delivery to the tumor; SDOSI is standard deviation of signal intensity. Significance of differences was assessed using Mann–Whitney test.
Table 4. Median standard deviation of signal intensity and its range on postcontrast T1-weighted images in the delayed phase after gadobutrol injection for cervical cancers of two histologic types (squamous cell carcinoma and adenocarcinoma) and different grades
Note. Significance of differences was assessed using Kruskal–Wallis test and then confirmed by Dunn’s paired test. * — p <0.03.
