Acknowledgements: the authors thank Daria Plakhina and Ivan Stetsenok of Genotek for their help and Sergey Glagolev of Moscow South-West High School No. 1543 for his valuable advice and comments.

Contribution of the authors to this work: Krasnenko AYu, Eliseev AYu — analysis of literature, research planning and implementation, data analysis and interpretation; Borisevich DI, Tsukanov KYu — bioinformatic analysis; Davydova AI — drafting of a manuscript; Ilinsky VV — research planning, scientific advisor. All authors participated in editing of the manuscript.