ORIGINAL RESEARCH

ZAIS-based colloidal QDs as fluorescent labels for theranostics: physical properties, biodistribution and biocompatibility

Istomina MS1,2, Pechnikova NA3,4, Korolev DV, Pochkayeva EI, Mazing DS2, Galagudza MM5, Moshnikov VA2, Shlyakhto EV
About authors

1 Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Peterburg, Russia

2 Department of Micro- and Nanoelectronics, St. Petersburg State Electrotechnical University “LETI”, St. Petersburg

3 Center of Experimental Pharmacology, St. Petersburg State Chemical Pharmaceutical Academy, St. Petersburg

4 Zoological Institute of Russian Academy of Sciences, St. Petersburg

5 Department of Pathophysiology, Pavlov First St. Petersburg State Medical University, St. Petersburg

Correspondence should be addressed: Maria S. Istomina
Parkhomenko 15 B, St. Petersburg, 194156; ur.liam@3991smanimotsi

Received: 2018-07-28 Accepted: 2018-08-23 Published online: 2018-12-24
|
  1. Melerzanov A, Moskalev A, Zharov V. Precizionnaja medicina i molekuljarnaja teranostika. Vrach. 2016; (12): 11–14.
  2. Gareev KG, Babikova KJu, Naumysheva EB, Postnov VN, Korolev DV. Sintez nanomaterialov s fluorescentnoj metkoj dlja medicinskogo naznachenija. Biotehnosfera. 2017; 3 (51): 61–8.
  3. Kobayashi H, Ogawa M, Alford R, Choyke PL, Urano Y. New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging. Chem Rev. 2010; 110 (5): 2620–40.
  4. Istomina MS, Korolev DV, Pochkaeva EI, Mazing DS, Moshnikov VA, Gareev KG, Babikova KJu, Postnov VN. issledovanie vozmozhnosti ispol'zovanija kolloidnyh kvantovyh tochek na osnove AgInS2/ ZnS dlja fluorescentnogo imidzhinga v sravnenii s fluoroforami, zakreplennymi na poverhnosti nanochastic. Transljacionnaja medicina. 2017; 4 (4): 56–65.
  5. Oh E, Liu R, Nel A, Gemill KB, Bilal M, Cohen Y, Medintz IL. Meta- analysis of cellular toxicity for cadmium-containing quantum dots. Nature nanotechnology. 2016; (11): 479–86.
  6. Tsoi KM, Dai Q, Alman BA, Chan WCW. Are quantum dots toxic? Exploring the discrepancy between cell culture and animal studies. Acc Chem Res. 2013; (46): 662–71.
  7. Ye L, Yong KT, Liu L et al. A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots. Nature Nanotech. 2012; (7): 453–8.
  8. Winnik FM, Maysinger D. Quantum dot cytotoxicity and ways to reduce it. Acc Chem Res. 2013; (46): 672–80.
  9. Ding Ya et al. Gold nanoparticles for nucleic acid delivery. Molecular therapy. 2014; 22 (6): 1075–83.
  10. Fitzpatrick JA. Andreko SK, Ernst LA, Waggoner AS, Ballou B, Bruchez MP. Long-term persistence and spectral blue shifting of quantum dots in vivo. Nano Lett. 2009; (9): 2736–41.
  11. Nel AE, Mädler L, Velegol D, Xia T, Hoek EM, Somasundaran P et al. Understanding biophysicochemical interactions at the nano–bio interface. Nature Mater. 2009; 8 (7): 543–57.
  12. Li MM, Cao J, Yang JC, Shen YJ, Cai XL, Chen YW et al. Biodistribution and toxicity assessment of intratumorally injected arginine-glycine-aspartic acid peptide conjugated to CdSe/ZnS quantum dots in mice bearing pancreatic neoplasm. Chem Biol Interact. 2018; (291): 103–10.
  13. Dine EJ, Marchal S, Schneider R, Hamie B, Ghanbaja J, Roques- Carmes T et al. A facile approach for doxorubicine delivery in cancer cells by responsive and fluorescent core/shell quantum dots. Bioconjug Chem. 2018; 29 (7): 2248–56.
  14. Lesnichaja MV, Suhov BG, Shendrik RJu, Sapozhnikov AN, Trofimov BA. Sintez vodorastvorimyh kvantovyh tochek selenida serebra, ljuminescirujushhih v okne prozrachnosti biologicheskih tkanej. Zhurnal obshhej himii. 2018; 88 (2): 307–10.
  15. Huang Y, Gao Y, Zhang Q, Zhang Y, Cao JJ, Ho W et al. Biocompatible FeOOH-Carbon quantum dots nanocomposites for gaseous NOx removal under visible light: Improved charge separation and High selectivity. J Hazard Mater. 2018; (354): 54–62.
  16. Drobintseva A, Polyakova V, Matyushkin L, Krylova Y, Masing D, Aleksandrova OA et al. Characterization of ZnSe/ZnS QD Conjugated with Antibody Labeling Kisspeptins. In 3-rd Int. Conf. of BioPhotonics, Florence, Italy. 2015.
  17. Alivisatos AP, Gu W, Larabell C. Quantum dots as cellular probes. Annu Rev Biomed Eng. 2005; (7): 55–76.
  18. Somers RC, Bawendi MG, Nocera DG. CdSe nanocrystal based chem-/bio-sensors. Chemical Society Reviews. 2007; 36 (4): 579–91.
  19. Shamirian A, Appelbe O, Zhang Q, Ganesh B, Kron SJ, Snee PT. A toolkit for bioimaging using near-infrared AgInS2/ZnS quantum dots. Journal of Materials Chemistry B. 2015; 3 (41): 8188–96.
  20. Bruchez M, Moronne M, Gin P, Weiss S, Alivisatos AP. Semiconductor nanocrystals as fluorescent biological labels. Science. 1998; 281 (5385): 2013–6.
  21. Chan WCW, Nie S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science. 1998; 281 (5385): 2016–8.
  22. Tyrakowski CM, Snee PT. A primer on the synthesis, water- solubilization, and functionalization of quantum dots, their use as biological sensing agents, and present status Physical Chemistry Chemical Physics. 2014; 16 (3): 837–55.
  23. Yaghini E, Turner HD, Le Marois AM, Suhling K, Naasani I, MacRobert AJ. In vivo biodistribution studies and ex vivo lymph node imaging using heavy metal-free quantum dots. Biomaterials. 2016; (104): 182–91.
  24. Matea CT, Mocan T, Tabaran F, et al. Quantum dots in imaging, drug delivery and sensor applications. International Journal of Nanomedicine. 2017; (12): 5421–31.
  25. Wang L-W, Peng C-W, Chen C, Li Y. Quantum dots-based tissue and in vivo imaging in breast cancer researches: current status and future perspectives. Breast Cancer Research and Treatment. 2015; 151 (1): 7–17.
  26. Wegner KD, Hildebrandt N. Quantum dots: bright and versatile in vitro and in vivo fluorescence imaging biosensors. Chemical Society Reviews. 2015; 44 (14): 4792–834.
  27. Walling MA, Novak JA, Shepard JRE. Quantum Dots for live cell and in vivo imaging. International Journal of Molecular Sciences. 2009; 10 (2): 441–91.
  28. Kang Yan-Fei et al. Carbon quantum dots for zebrafish fluorescence imaging. Scientific reports. 2005; (5): 11835.
  29. Xu G, Lin G, Lin S, Wu N, Deng Y, Feng G et al. The Reproductive Toxicity of CdSe/ZnS Quantum Dots on the in vivo Ovarian Function and in vitro Fertilization. Scientific reports. 2016; (6): 37677.
  30. Tang H, Yang ST, Yang YF, Ke DM, Liu JH, Chen X et al. Blood clearance, distribution, transformation, excretion, and toxicity of near-infrared quantum dots Ag2Se in mice. ACS applied materials & interfaces. 2018; 8 (28): 17859–69.
  31. Wang C, Gao X, Su X. In vitro and in vivo imaging with quantum dots. Analytical and bioanalytical chemistry. 2010; 397 (4): 1397–415.
  32. Gao J, Chen K, Xie R et al. In Vivo Tumor-targeted fluorescence imaging using near-infrared non-cadmium quantum dots. Bioconjugate chemistry. 2010; 21 (4): 604–9.
  33. Liu X, Zhou P, Zhan H, Liu H, Zhang J et al. Synthesis and characterization of near–infrared-emitting CdHgTe/CdS/ZnS quantum dots capped by N-acetyl-L-cysteine for in vitro and in vivo imaging. RSC Advances. 2017; 7 (48): 29998–30007.
  34. Lin G et al. Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots. International journal of nanomedicine. 2015; (10): 335.
  35. Singh SK et al. Drug delivery approaches for breast cancer. International journal of nanomedicine. 2017; (12): 6205.
  36. Han X, Wang Y, Shi D. Preparation of QDs@ SiO2/polystyrene composite particles for cancer cells detection. Nano LIFE. 2018.
  37. Jain S et al. Applications of Fluorescent Quantum Dots for Reproductive Medicine and Disease Detection. In: Park SB, editor. Rijeka: IntechOpen, 2018; 6.
  38. Schipper ML, Iyer G, Koh AL, Cheng Z, Ebenstein Y, Aharoni A et al. Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice. Small. 2009; 5 (1): 126–34.
  39. Yang L, Kuang H, Zhang W, Wei H, Xu H. Quantum dots cause acute systemic toxicity in lactating rats and growth restriction of offspring. Nanoscale. 2018; 10 (24): 11564–77.
  40. Roberts JR, Antonini JM, Porter DW et al. Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats. Particle and Fibre Toxicology. 2013; (10): 5.
  41. Park Y, Ryu YM, Jung Y et al. Spraying quantum dot conjugates in the colon of live animals enabled rapid and multiplex cancer diagnosis using endoscopy. ACS nano. 2014; 8 (9): 8896–910.
  42. Salykina YF, Zherdeva VV, Dezhurov SV et al. Biodistribution and clearance of quantum dots in small animals. Saratov Fall Meeting 2010: Optical Technologies in Biophysics and Medicine. 2011; (12): 7999.
  43. Roberts JR, Antonini JM, Porter DW et al. Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats. Particle and Fibre Toxicology. 2013; 10 (5).
  44. Park Y, Ryu YM, Jung Y et al. Spraying quantum dot conjugates in the colon of live animals enabled rapid and multiplex cancer diagnosis using endoscopy. ACS Nano. 2014; 7 (1): 9309.